Evidence map›Paper›PMID 32754823›Full record

ArticleCell stress & chaperones2020

Human molecular chaperones share with SARS-CoV-2 antigenic epitopes potentially capable of eliciting autoimmunity against endothelial cells: possible role of molecular mimicry in COVID-19.

Antonella Marino Gammazza, Sébastien Légaré, Giosuè Lo Bosco, Alberto Fucarino, Francesca Angileri, Everly Conway de Macario, Alberto Jl Macario, Francesco Cappello

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stress & chaperones, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 2 syntheses or guidelines pooled it, 112 citations in OpenAlex.

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  6. Microbiome and Long COVID-19: Current Evidence and Insights.International journal of molecular sciences · 2025
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Antonella Marino GammazzaDepartment of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, Palermo, Italy.
Sébastien LégaréDépartement d'Informatique de l'ÉNS, ÉNS, CNRS, Université PSL, Paris, France.
Giosuè Lo BoscoDepartment of Mathematics and Computer Science, University of Palermo, Palermo, Italy.
Alberto FucarinoDepartment of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, Palermo, Italy.
Francesca AngileriCentre Léon Bérard, Cancer Research Center of Lyon, Université de Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Lyon, France.
Everly Conway de MacarioDepartment of Microbiology and Immunology, School of Medicine, University of Maryland at Baltimore-Institute of Marine and Environmental Technology (IMET), Baltimore, MD, 21202, USA.
Alberto Jl MacarioDepartment of Microbiology and Immunology, School of Medicine, University of Maryland at Baltimore-Institute of Marine and Environmental Technology (IMET), Baltimore, MD, 21202, USA.
Francesco CappelloDepartment of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, Palermo, Italy. francesco.cappello@unipa.it.ORCID 0000-0001-9288-1148
University of Palermo · ITUniversity of Maryland, Baltimore · USCentre National de la Recherche Scientifique · FRIstituto Euro Mediterraneo di Scienza e Tecnologia · ITUniversité Claude Bernard Lyon 1 · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), the cause of COVID-19 disease, has the potential to elicit autoimmunity because mimicry of human molecular chaperones by viral proteins. We compared viral proteins with human molecular chaperones, many of which are heat shock proteins, to determine if they share amino acid-sequence segments with immunogenic-antigenic potential, which can elicit cross-reactive antibodies and effector immune cells with the capacity to damage-destroy human cells by a mechanism of autoimmunity. We identified the chaperones that can putatively participate in molecular mimicry phenomena after SARS-CoV-2 infection, focusing on those for which endothelial cell plasma-cell membrane localization has already been demonstrated. We also postulate that post-translational modifications, induced by physical (shear) and chemical (metabolic) stress caused respectively by the risk factors hypertension and diabetes, might have a role in determining plasma-cell membrane localization and, in turn, autoimmune-induced endothelial damage.

Indexed as

Heat-Shock ProteinsViral ProteinsAmino Acid SequenceAutoantigensAutoimmunityBetacoronavirusCoronavirus InfectionsCOVID-19Databases, ProteinEndothelial CellsHumansImmunodominant EpitopesMolecular MimicryPandemicsPneumonia, ViralSARS-CoV-2AutoantigensHeat-Shock ProteinsImmunodominant EpitopesViral ProteinsAutoimmunityCOVID-19EndothelialitisMolecular chaperonesMolecular mimicrySevere acute respiratory syndrome coronavirus 2

Identifiers

PMID32754823
PMCPMC7402394
OpenAlexW3047415564

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.