Evidence map›Paper›PMID 32754779›Full record

ArticleAIDS and behavior2021

Psychological Reactance is a Novel Risk Factor for Adolescent Antiretroviral Treatment Failure.

Elizabeth Lowenthal, Mitchelle Matesva, Tafireyi Marukutira, One Bayani, Jennifer Chapman, Ontibile Tshume, Mogomotsi Matshaba, Meredith Hickson, Robert Gross

Abstract read
In one paragraph

Article in AIDS and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Barriers to Antiretroviral Therapy Adherence Among Children in Ekurhuleni, South Africa: A Descriptive Study.International journal of environmental research and public health · 2026
    Article
  3. Article
  4. Article
  5. Adherence to Oral Contraception in Young Women: Beliefs, Locus of Control, and Psychological Reactance.International journal of environmental research and public health · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Elizabeth LowenthalThe Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA. lowenthale@email.chop.edu.ORCID http://orcid.org/0000-0002-3855-8646
Mitchelle MatesvaThe Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.
Tafireyi MarukutiraBotswana-Baylor Children's Clinical Centre of Excellence, Gaborone, Botswana.
One BayaniUniversity of Botswana School of Medicine, Gaborone, Botswana.
Jennifer ChapmanThe Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.
Ontibile TshumeBotswana-Baylor Children's Clinical Centre of Excellence, Gaborone, Botswana.
Mogomotsi MatshabaBotswana-Baylor Children's Clinical Centre of Excellence, Gaborone, Botswana.
Meredith HicksonThe Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.
Robert GrossDepartment of Medicine and Biostatistics, Epidemiology and Informatics Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI DAVID S METZGER · 1999 to 2026
$78.6M
Penn Mental Health AIDS Research CenterP30MH097488 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Karine Dube · 2013 to 2026
$23.5M
HIV Research Training Program for BotswanaD43TW009781 · FIC · UNIVERSITY OF PENNSYLVANIA · PI GROSS, ROBERT · 2014 to 2018
$1.7M
Targeted Monitoring and Determinants of Adherence in Adolescents with HIVK23MH095669 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI LOWENTHAL, ELIZABETH DAWN · 2012 to 2016
$874k
FIC NIH HHS D43 TW009781NIAID NIH HHS P30 AI045008NIH HHS D43 TW 009781NIH HHS K23 MH095669NIH HHS P30 AI 045008NIH HHS P30 MH097488NIMH NIH HHS K23 MH095669NIMH NIH HHS P30 MH097488
6 · The paper itself

Abstract

Psychological reactance is an aversive response to perceived threats against personal agency. For adolescents receiving HIV treatment in Botswana, we utilized a two-question, medication-specific reactance tool to assess whether: (1) verbal reminders to take medicines made adolescents want to avoid taking them, and, (2) whether adolescents felt anger when reminded to take medicines. Reactant adolescents had 2.05-fold (95% CI 1.23, 3.41) greater odds of treatment failure than non-reactant adolescents (p = 0.03). Adjusted risk of treatment failure was 14% (95% CI 3%, 28%) greater for each point elevation in reactance score (p = 0.016). Autonomy over medication-taking did not modify the association between reactance and treatment failure. Psychological reactance may be a useful interventional target for improving adolescent adherence.

Indexed as

HIV InfectionsAdolescentAnti-Retroviral AgentsBotswanaHumansMedication AdherenceRisk FactorsTreatment FailureAnti-Retroviral AgentsAdherenceAdolescent behaviorAfricaAntiretroviral therapyHIVPsychological reactance

Identifiers

PMID32754779
PMCPMC7858700

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.