ArticleFrontiers in cardiovascular medicine2020
Platelet Measurements and Type 2 Diabetes: Investigations in Two Population-Based Cohorts.
Article in Frontiers in cardiovascular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Insulin Resistance and Platelet Hyperactivity: Hematological Insights and Nutritional Strategies for Vascular Protection.Nutrients · 2026Review
- Platelets from older adults exhibit differences in mitochondrial function associated with impaired glucose metabolism.Clinical science (London, England : 1979) · 2026Article
- TEMR: Trans-ethnic mendelian randomization method using large-scale GWAS summary datasets.American journal of human genetics · 2025Article
- Therapies and delivery systems for diabetic wound care: current insights and future directions.Frontiers in pharmacology · 2025Review
- Impact of pneumatic tube vs. bicycle courier transport on platelet aggregation: influence of sex and diabetes.Frontiers in medicine · 2025Article
- Hs-CRP, Diabetic Status, and Adverse Events Among Patients Receiving Statin Therapy Following PCI-A Prospective Registry-Based Study.Journal of inflammation research · 2025Article
- Association between mean platelet volume and the risk of type 2 diabetes mellitus among women with history of gestational diabetes mellitus.BMC endocrine disorders · 2024Article
- Reduced platelet glycoprotein Ibα shedding accelerates thrombopoiesis and COX-1 recovery: implications for aspirin dosing regimen.Haematologica · 2023Article
- Article
- Insulin Resistance-Induced Platelet Hyperactivity and a Potential Biomarker Role of Platelet Parameters: A Narrative Review.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Review
- Type 2 Diabetes Mellitus, Platelet Activation and Alzheimer's Disease: A Possible Connection.Clinical neuropsychiatry · 2022Article
- Genetic Polymorphisms in the 3'-Untranslated Regions ofBiomedicines · 2022Article
- Article
- Hemorheological Parameters in Diabetic Patients: Role of Glucose Lowering Therapies.Metabolites · 2021Article
- Dapagliflozin reduces thrombin generation and platelet activation: implications for cardiovascular risk reduction in type 2 diabetes mellitus.Diabetologia · 2021Article
- Association between central non-dipping pattern and platelet morphology in adults with type 1 diabetes without cardiovascular disease: a cross-sectional study.Scientific reports · 2021Article
- Association between Neutrophilic Granulocyte Percentage and Diabetes Mellitus in Cushing's Syndrome Patients: A Cross-Sectional Study.International journal of endocrinology · 2021Article
- Integrative Genomic Analysis Reveals Four Protein Biomarkers for Platelet Traits.Circulation research · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Type 2 diabetes is a major risk factor for cardiovascular disease. Given the contribution of platelets to atherothrombosis-which in turn is a major contributor to cardiac events, there may be cause to consider platelet function in management of diabetes. Despite the large body of research concerning the role of platelets in cardiovascular complications of type 2 diabetes, evidence from population-based studies of platelet aggregation in diabetes is limited. Mean Platelet Volume (MPV), a cell trait partially associated with markers of platelet activity, is more commonly available. We investigated the association of metabolic syndrome and diabetes with platelet aggregation to three physiological agonists, ADP, collagen, and epinephrine, in the Framingham Heart Study Offspring cohort. We further examined the relationship between MPV measured with Beckman Coulter LH750 instruments and self-reported diabetes as well as MPV and diabetes medication in the UK BioBank cohort, performing the largest such analysis to date. Increased platelet aggregation associated with prevalent diabetes was observed for low concentration epinephrine (0.1 μM) alone and only in analyses of participants stratified either by male sex and/or having metabolic syndrome. Other agonists and concentrations were not significant for prevalent diabetes, or in opposite direction to the main hypothesis (i.e., they showed lower platelet aggregation associated with diabetes). After a median of 18.1 years follow-up, no platelet aggregation trait was associated with increased risk of diabetes (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.