ArticleFrontiers in cellular and infection microbiology2020
Early Bacterial Colonization and Antibiotic Resistance Gene Acquisition in Newborns.
Article in Frontiers in cellular and infection microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Trial
- High prevalence of blaBMC microbiology · 2026Article
- Prevalence and characterization of bacterial rectal colonization patterns in pediatric patients: A cross-sectional study.New microbes and new infections · 2026Article
- Molecular determinants ofFrontiers in cellular and infection microbiology · 2026Article
- Temporal dynamics & determinants of antibiotic resistance gene profiles in the infant gut during the first year of life.The Indian journal of medical research · 2025Article
- Prospective Whole-Genome Sequencing to Identify Bacterial Transmission and Its Modifiers in Neonates.JAMA network open · 2025Article
- Establishment of a risk prediction model for hydrocephalus complicated by neonatal bacterial meningitis.BMC infectious diseases · 2025Article
- Breastfeeding and early Bifidobacterium-driven microbial colonization shape the infant gut resistome.Nature communications · 2025Article
- Addressing the global challenge of bacterial drug resistance: insights, strategies, and future directions.Frontiers in microbiology · 2025Review
- Unravelling the evolutionary dynamics of antibiotic resistance genes in the infant gut microbiota during the first four months of life.Annals of clinical microbiology and antimicrobials · 2024Article
- Early life exposure of infants to benzylpenicillin and gentamicin is associated with a persistent amplification of the gut resistome.Microbiome · 2024Article
- Article
- Baseline azithromycin resistance in the gut microbiota of preterm born infants.Pediatric research · 2024Article
- Old Folks, Bad Boon: Antimicrobial Resistance in the Infant Gut Microbiome.Microorganisms · 2023Review
- The impacts of viral infection and subsequent antimicrobials on the microbiome-resistome of growing pigs.Microbiome · 2022Article
- Article
- The role ofGut microbesArticle
- Influence of age, socioeconomic status, and location on the infant gut resistome across populations.Gut microbesArticle
- Review
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several studies have recently identified the main factors contributing to the bacterial colonization of newborns and the dynamics of the infant microbiome development. However, most of these studies address large time periods of weeks or months after birth, thereby missing on important aspects of the early microbiome maturation, such as the acquisition of antibiotic resistance determinants during postpartum hospitalization. The pioneer bacterial colonization and the extent of its associated antibiotic resistance gene (ARG) dissemination during this early phase of life are largely unknown. Studies addressing resistant bacteria or ARGs in neonates often focus only on the presence of particular bacteria or genes from a specific group of antibiotics. In the present study, we investigated the gut-, the oral-, and the skin-microbiota of neonates within the first 72 h after birth using 16S rDNA sequencing approaches. In addition, we screened the neonates and their mothers for the presence of 20 different ARGs by directed TaqMan qPCR assays. The taxonomic analysis of the newborn samples revealed an important shift of the microbiota during the first 72 h after birth, showing a clear site-specific colonization pattern in this very early time frame. Moreover, we report a substantial acquisition of ARGs during postpartum hospitalization, with a very high incidence of macrolide resistance determinants and
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