ArticleHealthcare technology letters2020
Stimulus waveform design for decreasing charge and increasing stimulation selectivity in retinal prostheses.
Article in Healthcare technology letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 10 citations in OpenAlex.
- Extraocular Electrical Stimulation Activates Retinal Ganglion Cells In Vivo.bioRxiv : the preprint server for biology · 2026Article
- Impact of Aii Amacrine Cell Rewiring in a Pathoconnectome-Based Computational Model of Early Retinal Degeneration.bioRxiv : the preprint server for biology · 2026Article
- Toward Safety Protocols for Peripheral Nerve Stimulation (PNS): A Computational and Experimental Approach.Bioelectromagnetics · 2025Article
- An extraocular electrical stimulation approach to slow down the progression of retinal degeneration in an animal model.Scientific reports · 2023Article
- Impact of Retinal Degeneration on Response of ON and OFF Cone Bipolar Cells to Electrical Stimulation.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2023Article
- Selective Activation of Retinal Ganglion Cell Subtypes Through Targeted Electrical Stimulation Parameters.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2022Article
- Mechanisms underlying activation of retinal bipolar cells through targeted electrical stimulation: a computational study.Journal of neural engineering · 2021Article
- Model-based comparison of current flow in rod bipolar cells of healthy and early-stage degenerated retina.Experimental eye research · 2021Article
- Color and cellular selectivity of retinal ganglion cell subtypes through frequency modulation of electrical stimulation.Scientific reports · 2021Article
- Targeted Stimulation of Retinal Ganglion Cells in Epiretinal Prostheses: A Multiscale Computational Study.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Retinal degenerative diseases, such as retinitis pigmentosa, begin with damage to the photoreceptor layer of the retina. In the absence of presynaptic input from photoreceptors, networks of electrically coupled AII amacrine and cone bipolar cells have been observed to exhibit oscillatory behaviour and result in spontaneous firing of ganglion cells. This ganglion cell activity could interfere with external stimuli provided by retinal prosthetic devices and potentially degrade their performance. In this work, the authors computationally investigate stimulus waveform designs, which can improve the performance of retinal prostheses by suppressing undesired spontaneous firing of ganglion cells and generating precise temporal spiking patterns. They utilise a multi-scale computational model for electrical stimulation of degenerated retina based on the admittance method and NEURON simulation environments. They present a class of asymmetric biphasic pulses that can generate precise ganglion cell firing patterns with up to 55% lower current requirements compared to traditional symmetric biphasic pulses. This lower current results in activation of only proximal ganglion cells, provides more focused stimulation and lowers the risk of tissue damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.