ArticleHealthcare technology letters2020
Optical stimulation of neural tissue.
Article in Healthcare technology letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
- Thermophoresis induced by photothermal shock alters reversal potential and capacitance in neurons.Biophysical journal · 2026Article
- Differential Tissue-Coupled Powering for Battery-Free Injectable Electroceuticals.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- How spatial temperature gradients modulate infrared stimulation of the ex vivo rat sciatic nerve.Biophysical journal · 2025Article
- Electroceuticals: Unlocking the promise of therapies.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024Review
- Gold Nanorod-Embedded PDMS Micro-Pillar Array for Localized Photothermal Stimulation.Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems · 2024Article
- Fraxicon for Optical Applications with Aperture ∼1 mm: Characterisation Study.Nanomaterials (Basel, Switzerland) · 2024Article
- Advances in the Regulation of Neural Function by Infrared Light.International journal of molecular sciences · 2024Review
- Nanoparticle-based optical interfaces for retinal neuromodulation: a review.Frontiers in cellular neuroscience · 2024Review
- A snapshot review on materials enabled multimodal bioelectronics for neurological and cardiac research.MRS advances · 2023Article
- Emerging trends in the development of flexible optrode arrays for electrophysiology.APL bioengineering · 2023Review
- In-vitro quantitative measurement and analysis of the photosensitivity of cells to a weak pulse laser.Biomedical optics express · 2023Article
- G-Optrode Bio-Interfaces for Non-Invasive Optical Cell Stimulation: Design and Evaluation.Biosensors · 2022Article
- Theoretical simulation of the selective stimulation of axons in different areas of a nerve bundle by multichannel near-infrared lasers.Medical & biological engineering & computing · 2022Article
- Response of a neuronal network computational model to infrared neural stimulation.Frontiers in computational neuroscience · 2022Article
- Viral-mediated transduction of auditory neurons with opsins for optical and hybrid activation.Scientific reports · 2021Article
- Multifunctional Scaffolds and Synergistic Strategies in Tissue Engineering and Regenerative Medicine.Pharmaceutics · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Electrical stimulation has been used for decades in devices such as pacemakers, cochlear implants and more recently for deep brain and retinal stimulation and electroceutical treatment of disease. However, current spread from the electrodes limits the precision of neural activation, leading to a low quality therapeutic outcome or undesired side-effects. Alternative methods of neural stimulation such as optical stimulation offer the potential to deliver higher spatial resolution of neural activation. Direct optical stimulation is possible with infrared light, while visible light can be used to activate neurons if the neural tissue is genetically modified with a light sensitive ion channel. Experimentally, both methods have resulted in highly precise stimulation with little spread of activation at least in the cochlea, each with advantages and disadvantages. Infrared neural stimulation does not require modification of the neural tissue, but has very high power requirements. Optogenetics can achieve precision of activation with lower power, but only in conjunction with targeted insertion of a light sensitive ion channel into the nervous system via gene therapy. This review will examine the advantages and limitations of optical stimulation of neural tissue, using the cochlea as an exemplary model and recent developments for retinal and deep brain stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.