Evidence map›Paper›PMID 32754315›Full record

ArticleMolecular and clinical oncology2020

Development of diffuse large B-cell lymphoma after sofosbuvir-ledipasvir treatment for chronic hepatitis C: A case report and literature review.

Hiroyasu Sakai, Takao Miwa, Yoshikazu Ikoma, Tatsunori Hanai, Nobuhiko Nakamura, Kenji Imai, Junichi Kitagawa, Yohei Shirakami, Nobuhiro Kanemura, Atsushi Suetsugu and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Molecular and clinical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Cancer in People with and without Hepatitis C Virus Infection: Comparison of Risk Before and After Introduction of Direct-Acting Antivirals.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
    Observational
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Hiroyasu SakaiDepartment of Gastroenterology, Gifu University Hospital, Gifu 501-1194, Japan.
Takao MiwaDepartment of Gastroenterology, Gifu University Hospital, Gifu 501-1194, Japan.
Yoshikazu IkomaDepartment of Hematology, Gifu University Hospital, Gifu 501-1194, Japan.
Tatsunori HanaiDepartment of Gastroenterology, Gifu University Hospital, Gifu 501-1194, Japan.
Nobuhiko NakamuraDepartment of Hematology, Gifu University Hospital, Gifu 501-1194, Japan.
Kenji ImaiDepartment of Gastroenterology, Gifu University Hospital, Gifu 501-1194, Japan.
Junichi KitagawaDepartment of Hematology, Gifu University Hospital, Gifu 501-1194, Japan.
Yohei ShirakamiDepartment of Gastroenterology, Gifu University Hospital, Gifu 501-1194, Japan.
Nobuhiro KanemuraDepartment of Hematology, Gifu University Hospital, Gifu 501-1194, Japan.
Atsushi SuetsuguDepartment of Gastroenterology, Gifu University Hospital, Gifu 501-1194, Japan.
Koji TakaiDepartment of Gastroenterology, Gifu University Hospital, Gifu 501-1194, Japan.
Makoto ShirakiDepartment of Gastroenterology, Gifu University Hospital, Gifu 501-1194, Japan.
Masahito ShimizuDepartment of Gastroenterology, Gifu University Hospital, Gifu 501-1194, Japan.
Gifu University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, treatments for chronic hepatitis C virus (HCV) infection have significantly improved by the development of direct-acting antiviral agents (DAAs) and almost all patients with HCV can complete antiviral treatment without apparent adverse events. Malignant lymphoma, particularly B-cell non-Hodgkin's lymphoma, is one of the extrahepatic manifestations associated with chronic HCV infection. The effectiveness of anti-HCV therapy with DAAs for B-cell non-Hodgkin's lymphoma has been demonstrated in recent reports, whereas late-onset B-cell non-Hodgkin's lymphoma after HCV eradication with DAAs has occasionally been reported. In the present study, a 77-year-old man with chronic hepatitis C and intermediate liver cancer risk received sofosbuvir-ledipasvir treatment for 12 weeks. Two months following the end of antiviral therapy, he had achieved sustained virologic response for 8 weeks. However, the patient occasionally found swelling of the right cervical lymph nodes without any subjective symptoms. Lymph node biopsy revealed diffuse large B-cell lymphoma and whole-body

Indexed as

antiviral therapydiffuse large B-cell lymphomadirect-acting antiviral agentshepatitis C virusledipasvirsofosbuvir

Identifiers

PMID32754315
PMCPMC7391802
OpenAlexW3036511373

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.