Evidence map›Paper›PMID 32754192›Full record

ArticleFrontiers in genetics2020

A Long Non-coding RNA,

Alisa K Manning, Anton Scott Goustin, Erica L Kleinbrink, Pattaraporn Thepsuwan, Juan Cai, Donghong Ju, Aaron Leong, Miriam S Udler, James Bentley Brown, Mark O Goodarzi and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

Alisa K ManningClinical and Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA, United States.
Anton Scott GoustinCenter for Molecular Medicine & Genetics, Wayne State University, Detroit, MI, United States.
Erica L KleinbrinkCenter for Molecular Medicine & Genetics, Wayne State University, Detroit, MI, United States.
Pattaraporn ThepsuwanCenter for Molecular Medicine & Genetics, Wayne State University, Detroit, MI, United States.
Juan CaiCenter for Molecular Medicine & Genetics, Wayne State University, Detroit, MI, United States.
Donghong JuCenter for Molecular Medicine & Genetics, Wayne State University, Detroit, MI, United States.
Aaron LeongPrograms in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, United States.
Miriam S UdlerCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States.
James Bentley BrownDepartment of Statistics, University of California, Berkeley, Berkeley, CA, United States.
Mark O GoodarziDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, United States.
Robert SladekDepartment of Human Genetics, McGill University, Montréal, QC, Canada.
James B MeigsDepartment of Medicine, Harvard Medical School, Boston, MA, United States.
Leonard LipovichCenter for Molecular Medicine & Genetics, Wayne State University, Detroit, MI, United States.
Wayne State University · USMassachusetts General Hospital · USCedars-Sinai Medical Center · USHarbor–UCLA Medical Center · USMcGill University · CAThe Barbara Ann Karmanos Cancer Institute · USUniversity of California, Berkeley · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4M
Common Genetic Variation and Quantitative Diabetes TraitsR01DK078616 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MEIGS, JAMES B · 2008 to 2014
$5.0M
TOPMed Omics of Type 2 Diabetes and Quantitative TraitsUM1DK078616 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MANNING, ALISA KNODLE · 2021 to 2025
$3.8M
Rare Sequence Variation and Diabetes Quantitative TraitsU01DK078616 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MEIGS, JAMES B · 2015 to 2019
$3.6M
Life, Death, and Function: The Primate-Specific Long Non-Coding RNA TranscriptomeDP2CA196375 · NCI · WAYNE STATE UNIVERSITY · PI LIPOVICH, LEONARD · 2014 to 2014
$2.3M
Epidemiology of Precursors to Type 2 DiabetesK24DK080140 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MEIGS, JAMES B · 2007 to 2016
$1.9M
Clinical Implications of Genetically Defined Diabetes Subtypes and Application to Electronic Health Medical Record SystemsK23DK114551 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI UDLER, MIRIAM SARGON · 2017 to 2021
$1000k
Integrating diabetes pathophysiology from genotype to phenotype in whole genome sequence association studies of glycemic traitsK01DK107836 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MANNING, ALISA KNODLE · 2015 to 2018
$590k
NCATS NIH HHS UL1 TR001881NCI NIH HHS DP2 CA196375NIDDK NIH HHS K01 DK107836NIDDK NIH HHS K23 DK114551NIDDK NIH HHS K24 DK080140NIDDK NIH HHS L30 DK106874NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK078616NIDDK NIH HHS U01 DK078616NIDDK NIH HHS UM1 DK078616
6 · The paper itself

Abstract

aimsCausal transcripts at genomic loci associated with type 2 diabetes (T2D) are mostly unknown. The chr8p23.1 variant rs4841132, associated with an insulin-resistant diabetes risk phenotype, lies in the second exon of a long non-coding RNA (lncRNA) gene,

methodsWe tested our hypothesis using Stellaris fluorescent

resultsWe found that siRNA knockdown decreased

conclusionWe show that the lncRNA

Indexed as

hepatic glycogen storageinsulin resistancelong non-coding RNAmetabolismregulatory mechanismstype 2 diabetes

Identifiers

PMID32754192
PMCPMC7367044
OpenAlexW3041681986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.