ArticleFrontiers in psychiatry2020
Reduced Cortical Thickness in the Right Caudal Middle Frontal Is Associated With Symptom Severity in Betel Quid-Dependent Chewers.
Article in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Understanding betel nut addiction: a review of harmful consequences, underlying neurobiology, and emerging intervention strategies.Translational psychiatry · 2026Review
- A cross-sectional study on the knowledge, attitudes and practice of chewing areca nut and its risk factors among college students.Scientific reports · 2025Article
- Perceived stress and betel quid dependence associated with reasons for betel quid chewing among male chewers: a mixed methods study.BMC oral health · 2024Article
- Article
- Altered orbitofrontal and pars opercularis cortical thickness in betel quid dependence chewers.Therapeutic advances in psychopharmacology · 2024Article
- Factors in oral-related quality of life of betel quid users receiving oral mucosal screening: a cross‑sectional study in Taiwan.BMC oral health · 2023Article
- Altered Spontaneous Brain Activity in Betel Quid Dependence Chewers: A Resting-State Functional MRI Study With Percent Amplitude of Fluctuation.Frontiers in psychiatry · 2022Article
- Mapping white matter structural and network alterations in betel quid-dependent chewers using high angular resolution diffusion imaging.Frontiers in psychiatry · 2022Article
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Authors and funding
5 authors.
Funding
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Abstract
backgroundFindings from brain structural imaging studies on betel quid dependence have supported relations between betel quid chewing and alterations in gray matter volume and white matter integrity. However, the effect of betel quid chewing on cortical thickness and the link between cortical thickness and symptom severity remains unascertained.
methodsIn this observational study, we compared cortical thickness measures from 24 male betel quid-dependent chewers with 27 male healthy controls. Using FreeSufer, we obtained three-dimensional T1-weighted images that were used to compute the thickness of the cerebral cortex throughout the cortical layer.
resultsCompared to healthy controls, betel quid dependent chewers displayed significant decreased cortical thickness in the precuneus, entorhinal, right paracentral, middle temporal, and caudal middle frontal gyri. Betel quid dependence scale scores negatively correlated (r = -0.604;
conclusionThe findings provide evidence for cortical thickness abnormality in betel dependent chewers and further propose that the severity of betel quid symptoms may be a critical aspect associated with the cortical alterations. The observed alterations may serve as potential mechanisms to explain why BQ chewing behavior is persistent among individuals with betel quid dependence.
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