ReviewFrontiers in psychiatry2020
Herbal Therapies in Functional Gastrointestinal Disorders: A Narrative Review and Clinical Implication.
Review in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Herbal Formula Shenling Baizhu San for Chronic Diarrhea in Adults: A Systematic Review and Meta-analysis.Integrative cancer therapiesPooled it
- The effect of anti-nausea wristbands and STW-5 in children suffering from dyspepsia - a randomized double-blind placebo-controlled pilot-study.Klinische Padiatrie · 2026Trial
- Reprogramming the gastrointestinal microenvironment with intelligent biomaterials and digital medicine: a perspective on precision intervention for digestive diseases.Frontiers in bioengineering and biotechnology · 2026Article
- Natural Products in the Management of Gastroesophageal Reflux Disease: Mechanisms, Efficacy, and Future Directions.Nutrients · 2025Review
- Exploring the Prevalence of Functional Gastrointestinal Diseases and the Accompanied Differences in Dietary and Lifestyle Patterns: A Two-Generational Study.Diagnostics (Basel, Switzerland) · 2024Article
- Comparative Assessment of the Anti-Cells · 2024Article
- Article
- Identifying Novel Subtypes of Functional Gastrointestinal Disorder by Analyzing Nonlinear Structure in Integrative Biopsychosocial Questionnaire Data.Journal of clinical medicine · 2024Article
- Methane emission, nitrogen excretion, and energy partitioning in Hanwoo steers fed a typical TMR diet supplemented withFrontiers in veterinary science · 2024Article
- Food, Dietary Patterns, or Is Eating Behavior to Blame? Analyzing the Nutritional Aspects of Functional Dyspepsia.Nutrients · 2023Review
- Ethanol Extract of Mao Jian Green Tea Attenuates Gastrointestinal Symptoms in a Rat Model of Irritable Bowel Syndrome with Constipation via the 5-hydroxytryptamine Signaling Pathway.Foods (Basel, Switzerland) · 2023Article
- Cisplatin-Induced Nausea and Vomiting: Effect of Herbal Medicines.Plants (Basel, Switzerland) · 2022Review
- Gastrointestinal effects of Mentha aquatica L. essential oil.Inflammopharmacology · 2022Article
- Herbal therapies in gastrointestinal and hepatic disorders: An evidence-based clinical review.Frontiers in pharmacology · 2022Review
- Intestinal anti-inflammatory and visceral analgesic effects of aFrontiers in pharmacology · 2022Article
- Metabolite Profile, Ruminal Methane Reduction, and Microbiome Modulating Potential of Seeds ofFrontiers in microbiology · 2022Article
- In Vitro Screening of East Asian Plant Extracts for Potential Use in Reducing Ruminal Methane Production.Animals : an open access journal from MDPI · 2021Article
- Article
- Patient Suffering in Chronic Digestive Diseases: Will Primary Care-Specialist Collaboration With Effective Interactive Communication and Integrative Medicine in the Plan of Care Improve Quality of Life?Journal of patient experience · 2020Article
- Effects of sumac aqueous extract along with eating and drinking modification on functional dyspepsia symptoms in comparison with omeprazole: An open-label, randomized, controlled clinical trial.Avicenna journal of phytomedicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathophysiology of functional gastrointestinal disorders (FGIDs) is still unclear and various complex mechanisms have been suggested to be involved. In many cases, improvement of symptoms and quality of life (QoL) in patients with FGIDs is difficult to achieve with the single-targeted treatments alone and clinical application of these treatments can be challenging owing to the side effects. Herbal preparations as complementary and alternative medicine can control multiple treatment targets of FGIDs simultaneously and relatively safely. To date, many herbal ingredients and combination preparations have been proposed across different countries and together with a variety of traditional medicine. Among the herbal therapies that are comparatively considered to have an evidence base are iberogast (STW-5) and peppermint oil, which have been mainly studied and used in Europe, and rikkunshito and motilitone (DA-9701), which are extracted from natural substances in traditional medicine, are the focus of this review. These herbal medications have multi-target pharmacology similar to the etiology of FGIDs, such as altered intestinal sensory and motor function, inflammation, neurohormonal abnormality, and have displayed comparable efficacy and safety in controlled trials. To achieve the treatment goal of refractory FGIDs, extensive and high quality studies on the pharmacological mechanisms and clinical effects of these herbal medications as well as efforts to develop new promising herbal compounds are required.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.