ArticleFrontiers in physiology2020
The Effect of Five-Day Dry Immersion on the Nervous and Metabolic Mechanisms of the Circulatory System.
Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of weightlessness on the cardiovascular system: a systematic review and meta-analysis.Frontiers in physiology · 2024Pooled it
- Potentially Atherogenic Combined Biochemical and Physiological Changes in Human Antiorthostatic Hypokinesia.Bulletin of experimental biology and medicine · 2025Article
- Assessment of the effect of 21-day head-down bed rest on the cardiovascular system by blood protein composition.Frontiers in physiology · 2024Article
- Changes in the body fluids proteome as a reflection of the physiological effects of dry immersion.Frontiers in physiology · 2023Article
- Possibilities of Proteomics Profiling in Predicting Dysfunction of the Cardiovascular System.Frontiers in physiology · 2022Article
- Proteomic Characterization of Dry Blood Spots of Healthy Women During Simulation the Microgravity Effects Using Dry Immersion.Frontiers in physiology · 2021Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of the study was to investigate the regulatory and metabolic changes in the circulatory system when simulating microgravity conditions in a five-day dry immersion. These changes reflect the adaptation processes characteristic for the initial stages of a space flight or a short-duration space flight. Studies were conducted with 13 healthy male volunteers aged 21 to 29 years. The assessment of regulatory and metabolic processes in the circulatory system was based on the heart rate variability (HRV) and urine proteomic profile analysis. It was found that the restructuring of hemodynamics during 5 days hypogravity begins with the inclusion of the nervous circuit of regulation, and for manifestations at the body fluids protein composition level and activation of the metabolic regulation, these periods are apparently insufficient. Perhaps this is due to the fact that the metabolic regulation, being evolutionarily ancient and genetically determined, is more stable and requires more time for its pronounced activation when stimulated by extreme life conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.