Evidence map›Paper›PMID 32754008›Full record

ArticleMetabolomics : Official journal of the Metabolomic Society2017

Iridoid and phenylethanoid/phenylpropanoid metabolite profiles of

Korey J Brownstein, Mahmoud Gargouri, William R Folk, David R Gang

Open access · greenAbstract read
In one paragraph

Article in Metabolomics : Official journal of the Metabolomic Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Korey J BrownsteinWashington State University, Institute of Biological Chemistry, Pullman, Washington, 99164, USA.
Mahmoud GargouriWashington State University, Institute of Biological Chemistry, Pullman, Washington, 99164, USA.
William R FolkUniversity of Missouri, Department of Biochemistry, Columbia, Missouri, 65211, USA.
David R GangWashington State University, Institute of Biological Chemistry, Pullman, Washington, 99164, USA.
Washington State University · USUniversity of Missouri · US

Funding

Phased Exploratory Clinical Studies of Harpagophytum procumbens’ Impact upon the Biological Signature of Inflammatory OsteoarthritisR21AT009086 · NCCIH · UNIVERSITY OF MISSOURI KANSAS CITY · PI FOLK, WILLIAM ROBERT, GERKOVICH, MARY M. · 2016 to 2017
$515k
NCCIH NIH HHS R21 AT009086
6 · The paper itself

Abstract

introductionBotanicals containing iridoid and phenylethanoid/phenylpropanoid glycosides are used worldwide for the treatment of inflammatory musculoskeletal conditions that are primary causes of human years lived with disability (YLDs), such as arthritis and lower back pain.

objectivesWe report the analysis of candidate anti-inflammatory metabolites of several endemic

methodsLeaves, stems, and roots were analyzed by ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) and partial least squares-discriminant analysis (PLS-DA) was performed in MetaboAnalyst 3.0 after processing the datasets in Progenesis QI.

resultsComparison of the datasets revealed significant and differential accumulation of iridoid and phenylethanoid/phenylpropanoid glycosides in the tissues of the endemic

conclusionsOur investigation identified several species of pharmacological interest as good sources for harpagoside and other important anti-inflammatory metabolites.

Indexed as

Harpagosideiridoidphenylethanoid/phenylpropanoidScrophulariaverbascosideVerbascum

Identifiers

PMID32754008
PMCPMC7402375
OpenAlexW2763769216

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.