ArticleJournal of pain research2020
Hyperconnectivity and High Temporal Variability of the Primary Somatosensory Cortex in Low-Back-Related Leg Pain: An fMRI Study of Static and Dynamic Functional Connectivity.
Article in Journal of pain research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Connectomic Mapping of Chronic Musculoskeletal Pain: Neural Circuitries Identified Through a Systematic Review and ALE Meta-Analysis.Neural plasticity · 2026Pooled it
- Tuina Alleviates Pain Associated with Lumbar Disc Herniation by Regulating Functional Connectivity Between Inferior Frontal Triangularis and Multiple Brain Networks: A Randomized Controlled fMRI Study.Journal of pain research · 2026Trial
- Abnormal baseline brain activity in migraine without aura with versus without patent foramen ovale: a resting-state functional magnetic resonance imaging study.Neuroradiology · 2026Article
- Disrupted topological organization of brain connectome in patients with chronic low back related leg pain and clinical correlations.Scientific reports · 2025Article
- Divergent association between pain intensity and resting-state fMRI-based brain entropy in different age groups.Journal of neuroscience research · 2024Article
- The Alterations in the Brain Corresponding to Low Back Pain: Recent Insights and Advances.Neural plasticity · 2024Review
- Patient empowerment: a critical evaluation and prescription for a foundational definition.Frontiers in psychology · 2024Article
- Chronic pain as an emergent property of a complex system and the potential roles of psychedelic therapies.Frontiers in pain research (Lausanne, Switzerland) · 2024Article
- Research on the multidimensional brain remodeling mechanisms at the level of brain regions, circuits, and networks in patients with chronic lower back pain caused by lumbar disk herniation.Frontiers in neuroscience · 2024Article
- Role of Immersive Virtual Reality in Motor Behaviour Decision-Making in Chronic Pain Patients.Brain sciences · 2023Review
- Aberrant functional connectivity and temporal variability of the dynamic pain connectome in patients with low back related leg pain.Scientific reports · 2022Article
- Disrupted Dynamic Functional Connectivity of the Visual Network in Episodic Patients with Migraine without Aura.Neural plasticity · 2022Article
- The Effect of Long-Term Menstrual Pain on Large-Scale Brain Network in Primary Dysmenorrhea Patients.Journal of pain research · 2022Article
- Case report: The promising application of dynamic functional connectivity analysis on an individual with failed back surgery syndrome.Frontiers in neuroscience · 2022Article
- Carpal tunnel surgery dampens thalamocortical and normalizes corticocortical functional connectivity.Brain communications · 2022Article
- Non-invasive brain stimulation and pain neuroscience education in the cognitive-affective treatment of chronic low back pain: Evidence and future directions.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
- Changes in sensory-related brain networks of patients with moyamoya disease with limb paresthesia: A resting-state fMRI-based functional connectivity analysis.NeuroImage. Clinical · 2022Article
- Deficits in ascending pain modulation pathways in breast cancer survivors with chronic neuropathic pain: A resting-state fMRI study.Frontiers in neurology · 2022Article
- Pain and the Triple Network Model.Frontiers in neurology · 2022Review
- The Catastrophic Perception of Pain in Burning Mouth Syndrome May be Associated with Sympathetic Tone as Indicated by the QTc Interval.Innovations in clinical neuroscienceArticle
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Authors and funding
8 authors.
Funding
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Abstract
objectiveTo investigate the functional connectivity (FC) and its variability in the primary somatosensory cortex (S1) of patients with low-back-related leg pain (LBLP) in the context of the persistent stimuli of pain and numbness. PATIENTS AND
methodsWe performed functional magnetic resonance imaging on LBLP patients (n = 26) and healthy controls (HCs; n = 34) at rest. We quantified and compared static FC (sFC) using a seed-based analysis strategy, with 6 predefined bilateral paired spherical regions of interest (ROIs) in the S1 cortex. Then, we captured the dynamic FC using sliding window correlation of ROIs in both the LBLP patients and HCs. Furthermore, we performed a correlational analysis between altered static and dynamic FC and clinical measures in LBLP patients.
resultsCompared with controls, the LBLP patients had 1) significantly increased static FC between the left S1
conclusionThe present study demonstrated the hyperconnectivity of the S1 cortex to the default mode and executive control network in a spatial pattern and an increase in the tendency for signal variability in the internal network connections of the S1 cortex in patients with LBLP.
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