ArticleScientific reports2020
Hepatopancreas immune response during molt cycle in the mud crab, Scylla paramamosain.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 56 citations in OpenAlex.
- Molting in Pancrustacea Is Characterized by Both Deeply Conserved and Recently Evolved Gene Modules.Genome biology and evolution · 2026Article
- Transcriptomic Landscape Reveals Immunity Related Trade-Offs in an Invertebrate-Fungal Host-Parasite System.Molecular ecology · 2026Article
- Carbonate Alkalinity Stress Induces Hepatopancreas Injury and Activates TLR2-MyD88-NF-κB-Related Responses in Chinese Mitten Crab.Animals : an open access journal from MDPI · 2026Article
- Tributyrin enhances growth and intestinal health in green mud crab (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- De novo whole transcriptome sequencing reveals differentially expressed messenger RNA and MicroRNA in hepatopancreas ofAnimal cells and systems · 2026Article
- Transcriptome analysis of interna rootlets of the rhizocephalan Parasacculina sinensis reveals potential mechanisms of parasite host control.BMC genomics · 2025Article
- Regulation Roles of Juvenile Hormone Epoxide Hydrolase Gene 2 in the Female River PrawnCurrent issues in molecular biology · 2024Article
- Integrative Analysis of Hepatopancreas Transcriptome and Proteome in FemaleInternational journal of molecular sciences · 2024Article
- Responses of multifunctional immune complement component 1q (C1q) and apoptosis-related genes in Macrophthalmus japonicus tissues and human cells following exposure to environmental pollutants.Cell stress & chaperones · 2023Article
- Deciphering Molecular Mechanisms Governing the Reproductive Molt ofInternational journal of molecular sciences · 2023Article
- Whole-body transcriptome analysis provides insights into the cascade of sequential expression events involved in growth, immunity, and metabolism during the molting cycle in Scylla paramamosain.Scientific reports · 2022Article
- Comparative transcriptomics reveals the immune dynamics during the molting cycle of swimming crabFrontiers in immunology · 2022Article
- Comparative Transcriptome Analysis Reveals the Process of Ovarian Development and Nutrition Metabolism in Chinese Mitten Crab,Frontiers in genetics · 2022Article
- Molting Alters the Microbiome, Immune Response, and Digestive Enzyme Activity in Mud Crab (mSystems · 2021Article
- A newly identified Hippo homologue from the oriental river prawn Macrobrachium nipponense is involved in the antimicrobial immune response.Veterinary research · 2021Article
- Comparative Analysis of the Intermolt and Postmolt Hepatopancreas Transcriptomes Provides Insight into the Mechanisms ofLife (Basel, Switzerland) · 2021Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molt is a critical developmental process in crustaceans. Recent studies have shown that the hepatopancreas is an important source of innate immune molecules, yet hepatopancreatic patterns of gene expression during the molt cycle which may underlie changes in immune mechanism are unknown. In this study, we performed Illumina sequencing for the hepatopancreas of the mud crab, Scylla paramamosain during molt cycle (pre-molt stage, post-molt stage, and inter-molt stage). A total of 44.55 Gb high-quality reads were obtained from the normalized cDNA of hepatopancreas. A total of 70,591 transcripts were assembled; 55,167 unigenes were identified. Transcriptomic comparison revealed 948 differentially expressed genes (DEGs) in the hepatopancreas from the three molt stages. We found that genes associated with immune response patterns changed in expression during the molt cycle. Antimicrobial peptide genes, inflammatory response genes, Toll signaling pathway factors, the phenoloxidase system, antioxidant enzymes, metal-binding proteins and other immune related genes are significantly up-regulated at the post-molt stage and inter-molt stage compared with the pre-molt stage, respectively. These genes are either not expressed or are expressed at low levels at the pre-molt stage. To our knowledge, this is the first systematic transcriptome analysis of genes capable of mobilizing a hepatopancreas immune response during the molt cycle in crustaceans, and this study will contribute to a better understanding of the hepatopancreas immune system and mud crab prophylactic immune mechanisms at the post-molt stage.
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