Evidence map›Paper›PMID 32753714›Full record

ArticleScientific reports2020

A novel transgenic mouse strain expressing PKCβII demonstrates expansion of B1 and marginal zone B cell populations.

Ali A Azar, Alison M Michie, Anuradha Tarafdar, Natasha Malik, Geetha K Menon, Kathleen J Till, Nikolina Vlatković, Joseph R Slupsky

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. 2021 update on thyroid-associated ophthalmopathy.Journal of endocrinological investigation · 2022
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ali A AzarDepartment of Molecular and Clinical Cancer Medicine, University of Liverpool, 1st Floor Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK.
Alison M MichieMolecular Lymphopoiesis Group, Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0002-5404-475X
Anuradha TarafdarMolecular Lymphopoiesis Group, Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Natasha MalikMolecular Lymphopoiesis Group, Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0002-1768-3544
Geetha K MenonDepartment of Histopathology, Royal Liverpool University Hospital, Liverpool, UK.
Kathleen J TillDepartment of Molecular and Clinical Cancer Medicine, University of Liverpool, 1st Floor Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK.
Nikolina Vlatković *Department of Molecular and Clinical Cancer Medicine, University of Liverpool, 1st Floor Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK. vlatko@liverpool.ac.uk.
Joseph R Slupsky *Department of Molecular and Clinical Cancer Medicine, University of Liverpool, 1st Floor Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK. jslupsky@liverpool.ac.uk.ORCID http://orcid.org/0000-0002-7410-9004
University of Liverpool · GBUniversity of Glasgow · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein kinase Cβ (PKCβ) expressed in mammalian cells as two splice variants, PKCβI and PKCβII, functions in the B cell receptor (BCR) signaling pathway and contributes to B cell development. We investigated the relative role of PKCβII in B cells by generating transgenic mice where expression of the transgene is directed to these cells using the Eµ promoter (Eµ-PKCβIItg). Our findings demonstrate that homozygous Eµ-PKCβIItg mice displayed a shift from IgD

Indexed as

Gene Expression Regulation, EnzymologicGene Expression Regulation, LeukemicAnimalsAntigens, CDB-LymphocytesImmunoglobulin DImmunoglobulin MLeukemia, Lymphocytic, Chronic, B-CellMiceMice, TransgenicNeoplasm ProteinsProtein Kinase C betaReceptors, Antigen, B-CellSignal TransductionAntigens, CDImmunoglobulin DImmunoglobulin MNeoplasm ProteinsPrkcb protein, mouseProtein Kinase C betaReceptors, Antigen, B-Cell

Identifiers

PMID32753714
PMCPMC7403146
OpenAlexW3047250730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.