ArticleScientific reports2020
A genome-wide scan for candidate lethal variants in Thoroughbred horses.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Deficiency in homozygous haplotypes reveals recessive lethal variants affecting fertility and viability in the Friesian horse.BMC genomics · 2026Article
- Genomic Insights Into the Origin, Decline and Recovery of the Once Critically Endangered Iberian Lynx.Molecular ecology · 2025Review
- Effect of genomic regions harboring putative lethal haplotypes on reproductive performance in closed experimental selection lines of Nellore cattle.Scientific reports · 2025Article
- Massive detection of cryptic recessive genetic defects in dairy cattle mining millions of life histories.Genome biology · 2024Article
- Identification of candidate lethal haplotypes and genomic association with post-natal mortality and reproductive traits in Nellore cattle.Scientific reports · 2023Article
- Article
- Populations of NK Cells and Regulatory T Cells in the Endometrium of Cycling Mares-A Preliminary Study.Animals : an open access journal from MDPI · 2022Article
- Development and validation of a horse reference panel for genotype imputation.Genetics, selection, evolution : GSE · 2022Article
- Variations in the fecal microbiota and their functions of Thoroughbred, Mongolian, and Hybrid horses.Frontiers in veterinary science · 2022Article
- Impaired Reproductive Function in Equines: From Genetics to Genomics.Animals : an open access journal from MDPI · 2021Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Domestic animal populations are often characterised by high rates of inbreeding and low effective population sizes due to selective breeding practices. These practices can result in otherwise rare recessive deleterious alleles drifting to high frequencies, resulting in reduced fertility rates. This study aimed to identify potential recessive lethal haplotypes in the Thoroughbred horse breed, a closed population that has been selectively bred for racing performance. In this study, we identified a haplotype in the LY49B gene that shows strong evidence of being homozygous lethal, despite having high frequencies of heterozygotes in Thoroughbreds and other domestic horse breeds. Variant analysis of whole-genome sequence data identified two SNPs in the 3'UTR of the LY49B gene that may result in loss of function. Analysis of transcriptomic data from equine embryonic tissue revealed that LY49B is expressed in the trophoblast during placentation stage of development. These findings suggest that LY49B may have an essential, but as yet unknown function in the implantation stage of equine development. Further investigation of this region may allow for the development of a genetic test to improve fertility rates in horse populations. Identification of other lethal variants could assist in improving natural levels of fertility in horse populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.