ArticleScientific reports2020
X-ray microtomography is a novel method for accurate evaluation of small-bowel mucosal morphology and surface area.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 18 citations in OpenAlex.
- An X-ray micro-CT protocol enables non-destructive 3D visualization of glandular architecture in archived paraffin-embedded prostate cancer tissue.The journal of pathology. Clinical research · 2026Article
- Can micro-CT distinguish between solid lung tumors? A comparative evaluation including solid adenocarcinoma, non-keratinizing squamous cell carcinoma, and carcinoid tumor.Journal of pathology and translational medicine · 2026Article
- Micro-computed Tomography in the Evaluation of Eosin-stained Axillary Lymph Node Biopsies of Females Diagnosed with Breast Cancer.Scientific reports · 2024Article
- Article
- Optical imaging of the small intestine immune compartment across scales.Communications biology · 2023Article
- Validation of the X-ray microtomography in the assessment of duodenal morphometry and surface area in celiac disease.Frontiers in immunology · 2022Article
- Spatial analysis of histology in 3D: quantification and visualization of organ and tumor level tissue environment.Heliyon · 2022Article
- Differential diagnosis and long-term outcomes of non-atrophic duodenal changes in children.Frontiers in pediatrics · 2022Article
- Association of concomitant autoimmunity with the disease features and long-term treatment and health outcomes in Celiac disease.Frontiers in medicine · 2022Article
- Tutorial: methods for three-dimensional visualization of archival tissue material.Nature protocols · 2021Review
- Artificial intelligence in small intestinal diseases: Application and prospects.World journal of gastroenterology · 2021Review
- 3D-Non-destructive Imaging through Heavy-Metal Eosin Salt Contrast Agents.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Apolipoprotein A4 Defines the Villus-Crypt Border in Duodenal Specimens for Celiac Disease Morphometry.Frontiers in immunology · 2021Article
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Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The often poorly orientated small-bowel mucosal biopsies taken for the diagnostics of celiac disease and other intestinal disorders are prone to misinterpretation. Furthermore, conventional histopathology has suboptimal sensitivity for early histopathological changes observed in short-term challenge studies. X-ray microtomography (micro-CT) is a promising new method for accurate imaging of human-derived biological samples. Here, we report that micro-CT could be utilized to create virtual reconstructions of endoscopically obtained intestinal biopsies. The formed digital 3D images enabled selection of always optimal cutting angles for accurate measurement of the mucosal damage and revealed diagnostic lesions in cases interpreted as normal with conventional histomorphometry. We also demonstrate that computer-assisted point cloud analysis can be used to calculate biologically meaningful surface areas of the biopsies in different stages of mucosal damage with excellent replicability and correlation with other disease parameters. We expect the improved diagnostic accuracy and capability to measure the surface areas to provide a powerful tool for the diagnostics of intestinal diseases and for future clinical and pharmaceutical trials.
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