Evidence map›Paper›PMID 32753607›Full record

ArticleScientific reports2020

Treatment of mice with S4B6 IL-2 complex prevents lethal toxoplasmosis via IL-12- and IL-18-dependent interferon-gamma production by non-CD4 immune cells.

Andreas Kupz, Saparna Pai, Paul R Giacomin, Jennifer A Whan, Robert A Walker, Pierre-Mehdi Hammoudi, Nicholas C Smith, Catherine M Miller

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. The determinants regulatingFrontiers in microbiology · 2022
    Review
  6. Key Limitations and New Insights Into theFrontiers in cellular and infection microbiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Andreas KupzCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, 4878, Australia. andreas.kupz@jcu.edu.au.
Saparna PaiCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, 4878, Australia.
Paul R GiacominCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, 4878, Australia.
Jennifer A WhanAdvanced Analytical Centre, James Cook University, Cairns, QLD, 4878, Australia.
Robert A WalkerCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, 4878, Australia.
Pierre-Mehdi HammoudiDepartment of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland.ORCID http://orcid.org/0000-0002-8511-356X
Nicholas C SmithSchool of Science and Health, Western Sydney University, Parramatta South Campus, Sydney, NSW, 2116, Australia.ORCID http://orcid.org/0000-0002-7467-1451
Catherine M MillerCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, 4878, Australia.
Australian Institute of Tropical Health and Medicine · AUJames Cook University · AUUniversity of Geneva · CHUniversity of Technology Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Toxoplasmic encephalitis is an AIDS-defining condition. The decline of IFN-γ-producing CD4

Indexed as

AnimalsBrainInflammasomesInterferon-gammaInterleukin-12Interleukin-18Interleukin-2MiceToxoplasmaToxoplasmosisInflammasomesInterferon-gammaInterleukin-12Interleukin-18Interleukin-2

Identifiers

PMID32753607
PMCPMC7403597
OpenAlexW3047232101

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.