Evidence map›Paper›PMID 32753588›Full record

ArticleNature communications2020

Molecular design principles of Lysine-DOPA wet adhesion.

Yiran Li, Jing Cheng, Peyman Delparastan, Haoqi Wang, Severin J Sigg, Kelsey G DeFrates, Yi Cao, Phillip B Messersmith

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 159 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Catechol Derivative-Based Bioadhesives: Molecular Design for Precision Medical Adhesion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  8. Identification and characterization of a wet adhesive protein extracted fromProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. ACS omega · 2025
    Article
  16. Article
  17. Bond preservation in caries-affected dentin restored with acrylamide-based adhesives.Dental materials : official publication of the Academy of Dental Materials · 2025
    Article
  18. Mechanochemistry: Fundamental Principles and Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Yiran Li *Departments of Bioengineering and Materials Science and Engineering, University of California, Berkeley, CA, USA.
Jing Cheng *Departments of Bioengineering and Materials Science and Engineering, University of California, Berkeley, CA, USA.
Peyman Delparastan *Departments of Bioengineering and Materials Science and Engineering, University of California, Berkeley, CA, USA.ORCID http://orcid.org/0000-0003-4045-3381
Haoqi Wang *Department of Physics, Nanjing University, 210093, Nanjing, P. R. China.ORCID http://orcid.org/0000-0001-9147-4006
Severin J SiggDepartments of Bioengineering and Materials Science and Engineering, University of California, Berkeley, CA, USA.
Kelsey G DeFratesDepartments of Bioengineering and Materials Science and Engineering, University of California, Berkeley, CA, USA.ORCID http://orcid.org/0000-0002-3485-2477
Yi CaoDepartment of Physics, Nanjing University, 210093, Nanjing, P. R. China.ORCID http://orcid.org/0000-0003-1493-7868
Phillip B MessersmithDepartments of Bioengineering and Materials Science and Engineering, University of California, Berkeley, CA, USA. philm@berkeley.edu.ORCID http://orcid.org/0000-0002-1197-333X
University of California, Berkeley · USNanjing University · CNLawrence Berkeley National Laboratory · US

Funding

Biologically Inspired Polymer AdhesivesR37DE014193 · NIDCR · UNIVERSITY OF CALIFORNIA BERKELEY · PI MESSERSMITH, PHILLIP B · 2006 to 2015
$3.5M
Bioinspired Polymers for Fetal Membrane Pre-SealingR01EB022031 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI MESSERSMITH, PHILLIP B · 2016 to 2019
$1.3M
NIBIB NIH HHS R01 EB022031NIDCR NIH HHS R37 DE014193
6 · The paper itself

Abstract

The mussel byssus has long been a source of inspiration for the adhesion community. Recently, adhesive synergy between flanking lysine (Lys, K) and 3,4-Dihydroxyphenylalanine (DOPA, Y) residues in the mussel foot proteins (Mfps) has been highlighted. However, the complex topological relationship of DOPA and Lys as well as the interfacial adhesive roles of other amino acids have been understudied. Herein, we study adhesion of Lys and DOPA-containing peptides to organic and inorganic substrates using single-molecule force spectroscopy (SMFS). We show that a modest increase in peptide length, from KY to (KY)

Indexed as

AdhesivesAmino Acid SequenceAnimalsBivalviaDihydroxyphenylalanineDipeptidesLysinePeptidesSurface PropertiesTitaniumAdhesivesDihydroxyphenylalanineDipeptidesLysinePeptidesTitaniumtitanium dioxide

Identifiers

PMID32753588
PMCPMC7403305
OpenAlexW3047371915

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.