Evidence map›Paper›PMID 32753526›Full record

ArticleDisease models & mechanisms2020

Maltodextrin-induced intestinal injury in a neonatal mouse model.

Pratibha Singh, Lady Leidy Sanchez-Fernandez, David Ramiro-Cortijo, Pedro Ochoa-Allemant, George Perides, Yan Liu, Esli Medina-Morales, William Yakah, Steven D Freedman, Camilia R Martin

Open access · goldAbstract read
In one paragraph

Article in Disease models & mechanisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. State-of-the-art review and update ofFrontiers in pediatrics · 2023
    Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Pratibha SinghDivision of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Lady Leidy Sanchez-FernandezDivision of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
David Ramiro-CortijoDivision of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-7442-1586
Pedro Ochoa-AllemantDivision of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-7826-655X
George PeridesDivision of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Yan LiuDivision of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Esli Medina-MoralesDivision of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
William YakahDivision of Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Steven D FreedmanDivision of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Camilia R MartinDivision of Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA cmartin1@bidmc.harvard.edu.ORCID 0000-0003-2783-6126
Beth Israel Deaconess Medical Center · US

Funding

Impact of fatty acid imbalance in intestinal health and disease in prematurityR01DK104346 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MARTIN, CAMILIA R · 2014 to 2017
$2.8M
NIDDK NIH HHS R01 DK104346
6 · The paper itself

Abstract

Prematurity and enteral feedings are major risk factors for intestinal injury leading to necrotizing enterocolitis (NEC). An immature digestive system can lead to maldigestion of macronutrients and increased vulnerability to intestinal injury. The aim of this study was to test in neonatal mice the effect of maltodextrin, a complex carbohydrate, on the risk of intestinal injury. The goal was to develop a robust and highly reproducible murine model of intestinal injury that allows insight into the pathogenesis and therapeutic interventions of nutrient-driven intestinal injury. Five- to 6-day-old C57BL/6 mice were assigned to the following groups: dam fed (D); D+hypoxia+

Indexed as

Intestinal MucosaIntestine, SmallPolysaccharidesAnimalsAnimals, NewbornCytokinesDisease Models, AnimalEnterocolitis, NecrotizingGoblet CellsHypoxiaInflammation MediatorsKlebsiella pneumoniaeMice, Inbred C57BLMicrovilliMucin-2PermeabilityCytokinesInflammation MediatorsmaltodextrinMuc2 protein, mouseMucin-2PolysaccharidesTight Junction ProteinsIntestinal injuryMaltodextrinNecrotizing enterocolitisNeonatal mouse model

Identifiers

PMID32753526
PMCPMC7473650
OpenAlexW3046839491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.