Evidence map›Paper›PMID 32753498›Full record

ArticlemBio2020

Novel Antimicrobials from Uncultured Bacteria Acting against Mycobacterium tuberculosis.

Jeffrey Quigley, Aaron Peoples, Asel Sarybaeva, Dallas Hughes, Meghan Ghiglieri, Catherine Achorn, Alysha Desrosiers, Cintia Felix, Libang Liang, Stephanie Malveira and 8 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
0.5field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. A chlorinated diketopiperazine antibiotic targetsAntimicrobial agents and chemotherapy · 2025
    Article
  6. Lasso peptides: A focus on therapeutic index.World journal of microbiology & biotechnology · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Bacterial persisters: molecular mechanisms and therapeutic development.Signal transduction and targeted therapy · 2024
    Review
  13. Review
  14. Article
  15. Modern Trends in Natural Antibiotic Discovery.Life (Basel, Switzerland) · 2023
    Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Jeffrey QuigleyAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, Massachusetts, USA.
Aaron PeoplesNovoBiotic Pharmaceuticals, LLC, Cambridge, Massachusetts, USA.
Asel SarybaevaAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, Massachusetts, USA.
Dallas HughesNovoBiotic Pharmaceuticals, LLC, Cambridge, Massachusetts, USA.
Meghan GhiglieriAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, Massachusetts, USA.
Catherine AchornNovoBiotic Pharmaceuticals, LLC, Cambridge, Massachusetts, USA.
Alysha DesrosiersNovoBiotic Pharmaceuticals, LLC, Cambridge, Massachusetts, USA.
Cintia FelixNovoBiotic Pharmaceuticals, LLC, Cambridge, Massachusetts, USA.
Libang LiangAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, Massachusetts, USA.
Stephanie MalveiraAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, Massachusetts, USA.
William MillettNovoBiotic Pharmaceuticals, LLC, Cambridge, Massachusetts, USA.
Anthony NittiNovoBiotic Pharmaceuticals, LLC, Cambridge, Massachusetts, USA.
Baldwin TranNovoBiotic Pharmaceuticals, LLC, Cambridge, Massachusetts, USA.
Ashley ZulloNovoBiotic Pharmaceuticals, LLC, Cambridge, Massachusetts, USA.
Clemens AnklinBruker Biospin Corporation, Billerica, Massachusetts, USA.
Amy SpoeringNovoBiotic Pharmaceuticals, LLC, Cambridge, Massachusetts, USA.
Losee Lucy LingNovoBiotic Pharmaceuticals, LLC, Cambridge, Massachusetts, USA lling@novobiotic.com k.lewis@northeastern.edu.
Kim LewisAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, Massachusetts, USA lling@novobiotic.com k.lewis@northeastern.edu.ORCID 0000-0002-1335-9982
NovoBiotic Pharmaceuticals · USNortheastern University · USBruker (United States) · US

Funding

Uncultured bacteria for the discovery of novel antimicrobialsP01AI118687 · NIAID · NORTHEASTERN UNIVERSITY · PI LEWIS, KIM · 2016 to 2020
$8.9M
Specific anti-TB compounds from uncultured bacteriaR43AI118058 · NIAID · NOVOBIOTIC PHARMACEUTICALS, LLC · PI LING, LOSEE LUCY · 2015 to 2015
$219k
NIAID NIH HHS P01 AI118687NIAID NIH HHS R43 AI118058
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Drug DiscoveryAntitubercular AgentsHumansMycobacterium tuberculosisProtease InhibitorsTuberculosisAntitubercular AgentsProtease Inhibitorsantibioticantimicrobialdrug discoveryMycobacterium tuberculosisnatural product discoverynontuberculous mycobacteriaSec translocation

Identifiers

PMID32753498
PMCPMC7407088
OpenAlexW3047171841

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.