Evidence map›Paper›PMID 32753484›Full record

ArticleThe Journal of biological chemistry2020

AI26 inhibits the ADP-ribosylhydrolase ARH3 and suppresses DNA damage repair.

Xiuhua Liu, Rong Xie, Lily L Yu, Shih-Hsun Chen, Xiaoyun Yang, Anup K Singh, Hongzhi Li, Chen Wu, Xiaochun Yu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Xiuhua LiuCollege of Life Science, Institute of Life Science and Green Development, Hebei University, Baoding, Hebei, China.
Rong XieCollege of Life Science, Institute of Life Science and Green Development, Hebei University, Baoding, Hebei, China.
Lily L YuWestridge School, Pasadena, California, USA.
Shih-Hsun ChenInstitute of Biochemical Sciences, National Taiwan University, Taipei, Taiwan.
Xiaoyun YangCollege of Life Science, Institute of Life Science and Green Development, Hebei University, Baoding, Hebei, China.
Anup K SinghDepartment of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope, Duarte, California, USA.
Hongzhi LiDrug Discovery and Structural Biology Core Facility, Beckman Research Institute, City of Hope, Duarte, California, USA.
Chen WuCollege of Life Science, Institute of Life Science and Green Development, Hebei University, Baoding, Hebei, China.
Xiaochun YuSchool of Life Sciences, Westlake University, Hangzhou, Zhejiang, China. Electronic address: yuxiaochun@westlake.edu.cn.
Hebei University · CNBeckman Research InstituteCancer Genetics (United States) · USNational Taiwan University · TWWestlake University · CN

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3M
Regulation of Ionizing Radiation-Induced DNA Damage ResponseR01CA130899 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIU, YILUN · 2009 to 2023
$5.5M
Molecular Mechanisms of BRCA1-Dependent DNA Damage Response and TumorogenesisR01CA132755 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHEN, BINGHUI · 2008 to 2019
$3.5M
DNA repair gene mutations and prostate cancerR01CA233664 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI SHEN, BINGHUI, SUN, ZIJIE · 2020 to 2024
$3.4M
The role of O-GlcNAcylation in DNA damage repair and cancer therapyR01CA240392 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI STARK, JEREMY MICHAEL · 2019 to 2023
$2.0M
NCI NIH HHS P30 CA033572NCI NIH HHS R01 CA130899NCI NIH HHS R01 CA132755NCI NIH HHS R01 CA233664NCI NIH HHS R01 CA240392
6 · The paper itself

Abstract

The ADP-ribosylhydrolase ARH3 plays a key role in DNA damage repair, digesting poly(ADP-ribose) and removing ADP-ribose from serine residues of the substrates. Specific inhibitors that selectively target ARH3 would be a useful tool to examine DNA damage repair, as well as a possible strategy for tumor suppression. However, efforts to date have not identified any suitable compounds. Here, we used

Indexed as

DNA DamageCell Line, TumorDNA RepairEnzyme InhibitorsGlycoside HydrolasesHumansADPRS protein, humanEnzyme InhibitorsGlycoside HydrolasesADP-ribosylationARH3cancer therapydePARylationDNA damage responseDNA repairinhibitor

Identifiers

PMID32753484
PMCPMC7535916
OpenAlexW3047526604

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.