Evidence map›Paper›PMID 32753395›Full record

ArticleEmergency medicine journal : EMJ2020

Identification of very low-risk acute chest pain patients without troponin testing.

Lane M Smith, Nicklaus P Ashburn, Anna C Snavely, Jason P Stopyra, Kristin M Lenoir, Brian J Wells, Brian C Hiestand, David M Herrington, Chadwick D Miller, Simon A Mahler

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Emergency medicine journal : EMJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Cardiovascular Risk Assessment Tools in CKD.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Review
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  10. Article
  11. A Closer Look at the HEART Score.Cardiology research · 2022
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Lane M SmithEmergency Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA lane_smith@bellsouth.net.ORCID http://orcid.org/0000-0002-7418-3351
Nicklaus P AshburnEmergency Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Anna C SnavelyBiostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Jason P StopyraEmergency Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Kristin M LenoirBiostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Brian J WellsBiostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Brian C HiestandEmergency Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
David M HerringtonInternal Medicine, Section on Cardiovascular Science, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Chadwick D MillerEmergency Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Simon A MahlerEmergency Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Wake Forest University · US

Funding

Study of Treatment's Echocardiographic Mechanisms (CLOVERS-STEM)R01HL144624 · NHLBI · IHC HEALTH SERVICES, INC. · PI BROWN, SAMUEL MORRIS · 2019 to 2022
$1.8M
NHLBI NIH HHS L30 HL120008NHLBI NIH HHS R01 HL144624
6 · The paper itself

Abstract

backgroundThe HEART Pathway combines a History ECG Age Risk factor (HEAR) score and serial troponins to risk stratify patients with acute chest pain. However, it is unclear whether patients with HEAR scores of

methodsA secondary analysis of the HEART Pathway Implementation Study was conducted. HEART Pathway risk assessments (HEAR scores and serial troponin testing at 0 and 3 hours) were completed by the providers on adult patients with chest pain from three US sites between November 2014 and January 2016. MACE (composite of death, myocardial infarction (MI) and coronary revascularisation) at 30 days was determined. The proportion of patients with HEAR scores of

resultsProviders completed HEAR assessments on 4979 patients and HEAR scores<1 occurred in 9.0% (447/4979) of patients. Among these patients, MACE at 30 days occurred in 0.9% (4/447; 95% CI 0.2% to 2.3%) with two deaths, two MIs and 0 revascularisations. The sensitivity and negative predictive value for MACE in the HEAR

conclusionThese data suggest that patients with HEAR scores of 0 and 1 represent a very low-risk group that may not require troponin testing to achieve a missed MACE rate <1%.

Indexed as

Acute DiseaseAdultBiomarkersChest PainDiagnosis, DifferentialFemaleHumansMaleMiddle AgedNorth CarolinaPredictive Value of TestsRisk AssessmentSensitivity and SpecificityTroponinUnited StatesBiomarkersTroponinacute coronary syndromecardiac care, acute coronary syndromecardiac care, acute myocardal infarctcardiac care, diagnosisECG

Identifiers

PMID32753395
PMCPMC7952041
OpenAlexW3047092659

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.