ReviewBiological psychiatry2021
Adolescent Attention-Deficit/Hyperactivity Disorder: Understanding Teenage Symptom Trajectories.
Review in Biological psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Longitudinal MRI studies of children with attention-deficit/hyperactivity disorder: A systematic review.Psychiatry and clinical neurosciences · 2026Pooled it
- Different functional alteration in attention-deficit/hyperactivity disorder across developmental age groups: A meta-analysis and an independent validation of resting-state functional connectivity studies.CNS neuroscience & therapeutics · 2023Pooled it
- Developmental deviations of association-network structural connectivity in youths with ADHD predict symptom and treatment outcomes.Nature biomedical engineering · 2026Article
- Altered flow of information in attention-deficit/hyperactivity disorder.Translational psychiatry · 2026Article
- ADHD symptom trajectories and brain morphometry: A longitudinal analysis.medRxiv : the preprint server for health sciences · 2026Article
- Developmental trajectories of glutamate and the variable clinical course of ADHD in youth.Translational psychiatry · 2026Article
- Adult-diagnosed and childhood-diagnosed attention deficit/hyperactivity disorder: cognitive and environmental contributions to symptom severity across different age of diagnosis.Frontiers in psychiatry · 2026Article
- A Network Analysis of ADHD and ASD Symptoms in Chinese Children: Insights on Age and Gender Differences.International journal of methods in psychiatric research · 2025Article
- Cut from the same cloth: neurobiological continuity between childhood and adult ADHD.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Hair cortisol concentration and mental health during childhood and adolescence: evidence that higher cortisol concentration is associated with externalizing problems in a large Brazilian population-based birth cohort.European child & adolescent psychiatry · 2025Article
- Peer Preference and Executive Functioning Development: Longitudinal Relations Among Females With and Without ADHD.Research on child and adolescent psychopathology · 2025Article
- Trigeminal Nerve Stimulation (TNS) for Children with Attention Deficit/Hyperactivity Disorder and Fetal Alcohol Spectrum Disorder: Feasibility Study Protocol.medRxiv : the preprint server for health sciences · 2025Article
- Lifetime Contacts with Child Welfare Services among Children and Adolescents with ADHD: A Population-Based Registry Study.Child psychiatry and human development · 2025Article
- ADHD in Adults with Epilepsy: A Guide for Neurologists.Epilepsy & behavior reports · 2025Article
- Article
- Modeling Shared and Specific Variances of Irritability, Inattention, and Hyperactivity Yields Novel Insights Into White Matter Perturbations.Journal of the American Academy of Child and Adolescent Psychiatry · 2024Article
- Cortico-striatal differences in the epigenome in attention-deficit/ hyperactivity disorder.Translational psychiatry · 2024Article
- Mentalizing in Adolescents and Young Adults with Attention Deficit Hyperactivity Disorder: Associations with Age and Attention Problems.Psychopathology · 2024Article
- Advances in the etiology and neuroimaging of children with attention deficit hyperactivity disorder.Frontiers in pediatrics · 2024Review
- The Limbic System in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder: A Longitudinal Structural Magnetic Resonance Imaging Analysis.Biological psychiatry global open science · 2024Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Symptoms of attention-deficit/hyperactivity disorder (ADHD) run a variable course through adolescence. While most affected individuals show some improvement, particularly of hyperactivity-impulsivity, symptoms of inattention are more persistent, and some individuals may meet diagnostic criteria for the first time during adolescence. Genetic factors affect adolescent symptom trajectories; those showing persistence likely carry a greater burden of common risk alleles. Rare structural genomic variants, such as copy number variants and point mutations, might also play a role. Although psychostimulant medication is associated with better functional outcomes, an impact on underlying adolescent symptom trajectories has been hard to demonstrate. At a neural level, several studies report that adolescents whose childhood ADHD symptoms have remitted are indistinguishable from neurotypical individuals. This finding could reflect the "carrying forward" of relatively typical childhood neural features among those destined for adolescent remission or the correction of early childhood anomalies with a convergence toward typical dimensions. Other studies have noted unique, possibly compensatory patterns of neural activity among adolescents whose ADHD has improved. Finally, different neural processes might occur in different brain regions. Thus, some functional imaging studies find that subcortical anomalies reflect the onset of ADHD and remain throughout life regardless of symptom change, whereas the variable clinical course of adolescent ADHD is determined by plasticity of the cerebral cortex. Integrating an understanding of the neural processes with genomic risk could elucidate the mechanisms underlying the complex course of adolescent ADHD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.