Evidence map›Paper›PMID 32753114›Full record

SynthesisBrazilian journal of anesthesiology (Elsevier)

[Neurokinin-1 receptor antagonists for postoperative nausea and vomiting: a systematic review and meta-analysis].

Chiaki Murakami, Nami Kakuta, Shiho Satomi, Ryuji Nakamura, Hirotsugu Miyoshi, Atsushi Morio, Noboru Saeki, Takahiro Kato, Naohiro Ohshita, Katsuya Tanaka and 1 more

Open access · diamondAbstract readComparative StudyMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Brazilian journal of anesthesiology (Elsevier). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Chiaki MurakamiTokushima University, Department of Anesthesiology, Kumamoto, Japão.
Nami KakutaTokushima University, Department of Anesthesiology, Kumamoto, Japão.
Shiho SatomiUniversity of California, Department of Anesthesiology, San Diego, EUA.
Ryuji NakamuraHiroshima University, Department of Anesthesiology and Critical Care, Minami, Japão.
Hirotsugu MiyoshiHiroshima University, Department of Anesthesiology and Critical Care, Minami, Japão.
Atsushi MorioHiroshima University, Department of Anesthesiology and Critical Care, Minami, Japão.
Noboru SaekiHiroshima University, Department of Anesthesiology and Critical Care, Minami, Japão.
Takahiro KatoHiroshima University, Department of Anesthesiology and Critical Care, Minami, Japão.
Naohiro OhshitaOsaka Dental University, Department of Anesthesiology, Chuo, Japão.
Katsuya TanakaTokushima University, Department of Anesthesiology, Kumamoto, Japão.
Yasuo M TsutsumiHiroshima University, Department of Anesthesiology and Critical Care, Minami, Japão. Electronic address: yasuo223@hiroshima-u.ac.jp.
Hiroshima University · JPTokushima University · JPOsaka Dental University · JPUniversity of California San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative Nausea and Vomiting (PONV) is a common complication of general anesthesia. Several kinds of antiemetics, including 5-Hydroxytryptamine3 (5-HT3) receptor antagonists and Neurokinin-1 (NK-1) receptor antagonists, have been used to treat PONV.

objectivesTo compare the antiemetic effect of NK-1 receptor antagonists, including fosaprepitant. DATA SOURCES: Online databases (PubMed, MEDLINE, Scopus, The Cochrane Library databases) were used. STUDY ELIGIBILITY CRITERIA, PARTICIPANTS, AND

interventionsRandomized Controlled Trials (RCTs) performed in patients over 18 years with ASA-PS of I-III, aimed to assess the efficacy of antiemetics including NK-1 receptor antagonists and 5-HT3 receptor antagonists, and compared the incidence of PONV were included. STUDY APPRAISAL AND SYNTHESIS

methodsAll statistical assessments were conducted by a random effect approach and odds ratios and 95% Confidence Intervals were calculated.

resultsAprepitant 40mg and 80mg significantly reduced the incidence of vomiting 0-24hours postoperatively (Odds Ratio [OR = 0.40]; 95% Confidence Interval [95% CI 0.30-0.54]; p < 0.001, and OR = 0.32; 95% CI 0.19-0.56; p < 0.001). Fosaprepitant could also reduce the incidence of vomiting significantly both 0-24h and 0-48hours postoperatively (OR = 0.07; 95% CI 0.02-0.24; p < 0.001 and OR = 0.07; 95% CI 0.02-0.23; p < 0.001). LIMITATIONS: Risk factors for PONV are not considered, RCTs using multiple antiemetics are included, RCTs for fosaprepitant is small, and some bias may be present. CONCLUSIONS AND IMPLICATIONS OF KEY

findingsAprepitant and fosaprepitant can be effective prophylactic antiemetics for postoperative vomiting. However, more studies are required for higher-quality meta-analyses. SYSTEMATIC REVIEW REGISTRATION NUMBER: CRD42019120188.

Indexed as

Anesthesia, GeneralAntiemeticsHumansIncidenceMorpholinesNeurokinin-1 Receptor AntagonistsPostoperative Nausea and VomitingRandomized Controlled Trials as TopicSerotonin 5-HT3 Receptor AntagonistsAntiemeticsfosaprepitantMorpholinesNeurokinin-1 Receptor AntagonistsSerotonin 5-HT3 Receptor AntagonistsAntagonistas do receptor NK‐1Náusea e vômito no pós‐operatórioNK‐1 receptor antagonistsPostoperative nausea and vomitingProfilaxiaProphylaxisTratamentoTreatment

Identifiers

PMID32753114
PMCPMC9373091
OpenAlexW3037060028

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.