ArticleBMC medicine2020
Does parity matter in women's risk of dementia? A COSMIC collaboration cohort study.
Article in BMC medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 76 citations in OpenAlex.
- [Dementia and Parkinson's Disease in the rural population of western Salamanca: a cross-sectional study of prevalence and family support needs].Atencion primaria · 2026Article
- Effect of Parity and β-Amyloid on Cognition and Hippocampal Volume in Postmenopausal Women.Neurology · 2026Article
- Causal effects of reproductive traits on cognitive function: A two-sample and multivariable mendelian randomization study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
- Women's reproductive life patterns, intrinsic capacity, and the risk of all-cause and cause-specific dementia: a prospective cohort study.Alzheimer's research & therapy · 2026Article
- Lifetime Exposure to Endogenous Estradiol and Markers of Dementia Risk: Associations with Later Life Cognitive, Behavioral, and Functional Complaints.Diagnostics (Basel, Switzerland) · 2026Article
- Multiparity exacerbates Aβ accumulation and promotes cellular senescence in a mouse model of amyloidosis.Immunity & ageing : I & A · 2026Article
- Abdominal CT-derived metabolic phenotypes are associated with the MRI-derived brain age gap in women.Frontiers in aging neuroscience · 2026Article
- Lower birth rate, greater female dementia risk: global and regional patterns and public health implications.Future science OA · 2025Article
- Refining Western Dementia-Risk Paradigms: Evidence From a Decade of the Korean Longitudinal Study on Cognitive Aging and Dementia.Journal of Korean medical science · 2025Review
- Biological and social reproductive factors and late-life cognitive function in middle-aged and older Chinese women.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Article
- Risk of Alzheimer's disease in Down syndrome: Insights gained by multi-omics.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Number of children and risk of dementia: a cohort study.Journal of epidemiology and community health · 2025Article
- Previous parity differentially influences cognition in later life depending on dementia status.NPJ dementia · 2025Article
- Childbearing Histories and Midlife Cognition: Accounting for Early Life Factors.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- Enhancing brain health in the Global South through sex and gender lens.Nature. Mental health · 2024Article
- Impact of the South African Child Support Grant on memory decline and dementia probability in rural and low-income mothers, 2014-2021.Social science & medicine (1982) · 2024Article
- Higher Number of Children Is Associated With Increased Risk of Generalization Deficits in Older African American Women.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- Connections between reproductive health and cognitive aging among women enrolled in the HCHS/SOL and SOL-INCA.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Effects of reproductive experience on cost-benefit decision making in female rats.Frontiers in behavioral neuroscience · 2024Article
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Authors and funding
47 authors at 20 institutions in 14 countries.
Funding
Abstract
backgroundDementia shows sex difference in its epidemiology. Childbirth, a distinctive experience of women, is associated with the risk for various diseases. However, its association with the risk of dementia in women has rarely been studied.
methodsWe harmonized and pooled baseline data from 11 population-based cohorts from 11 countries over 3 continents, including 14,792 women aged 60 years or older. We investigated the association between parity and the risk of dementia using logistic regression models that adjusted for age, educational level, hypertension, diabetes mellitus, and cohort, with additional analyses by region and dementia subtype.
resultsAcross all cohorts, grand multiparous (5 or more childbirths) women had a 47% greater risk of dementia than primiparous (1 childbirth) women (odds ratio [OR] = 1.47, 95% confidence interval [CI] = 1.10-1.94), while nulliparous (no childbirth) women and women with 2 to 4 childbirths showed a comparable dementia risk to primiparous women. However, there were differences associated with region and dementia subtype. Compared to women with 1 to 4 childbirths, grand multiparous women showed a higher risk of dementia in Europe (OR = 2.99, 95% CI = 1.38-6.47) and Latin America (OR = 1.49, 95% CI = 1.04-2.12), while nulliparous women showed a higher dementia risk in Asia (OR = 2.15, 95% CI = 1.33-3.47). Grand multiparity was associated with 6.9-fold higher risk of vascular dementia in Europe (OR = 6.86, 95% CI = 1.81-26.08), whereas nulliparity was associated with a higher risk of Alzheimer disease (OR = 1.91, 95% CI 1.07-3.39) and non-Alzheimer non-vascular dementia (OR = 3.47, 95% CI = 1.44-8.35) in Asia.
conclusionParity is associated with women's risk of dementia, though this is not uniform across regions and dementia subtypes.
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