Evidence map›Paper›PMID 32753036›Full record

ReviewParticle and fibre toxicology2020

Effects of particulate matter on atherosclerosis: a link via high-density lipoprotein (HDL) functionality?

Siri A N Holme, Torben Sigsgaard, Jørn A Holme, Gitte Juel Holst

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Particle and fibre toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Siri A N HolmeDepartment of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark.
Torben SigsgaardResearch Unit of Environment, Occupation and Health, Department of Public Health, Aarhus University, Aarhus, Denmark. ts@ph.au.dk.ORCID 0000-0002-2043-7571
Jørn A HolmeDepartment of Environmental Health, Division of Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway.
Gitte Juel HolstResearch Unit of Environment, Occupation and Health, Department of Public Health, Aarhus University, Aarhus, Denmark.
Aarhus University · DKNorwegian Institute of Public Health · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExposure to air pollution has been associated with adverse effects on human health, and ultimately increased morbidity and mortality. This is predominantly due to hazardous effects on the cardiovascular system. Exposure to particulate matter (PM) is considered to be responsible for the most severe effects. MAIN BODY: Here we summarize current knowledge from existing epidemiological, clinical and animal studies on the influence of PM exposure on high-density lipoprotein (HDL) functionality and the potential initiation and progression of atherosclerosis. We highlight experimental studies that bring support to the causality and point to possible mechanistic links. Recent studies indicate that the functional properties of HDL are more important than the levels per se. Fine (PM

conclusionCurrent literature suggests that PM promotes HDL dysfunction via oxidative pathways. However, as relatively few studies so far have evaluated the impact of particulate air pollution on HDL functionality, more human epidemiological as well as experimental studies are needed to strengthen any possible causal relationship and determine any relevance to atherosclerosis.

Indexed as

AtherosclerosisAir PollutantsAir PollutionAnimalsHumansLipoproteins, HDLOxidation-ReductionOxidative StressParticle SizeParticulate MatterAir PollutantsLipoproteins, HDLParticulate MatterAir pollutionAtherosclerosisCardiovascular diseaseHigh-density-lipoproteinInflammationLipoproteinsOxidative stressParticulate matter

Identifiers

PMID32753036
PMCPMC7409402
OpenAlexW3047484023

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.