Evidence map›Paper›PMID 32752898›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2020

Cytotoxic substituted indolizines as new colchicine site tubulin polymerisation inhibitors.

Monica-Cornelia Sardaru, Anda Mihaela Craciun, Cristina-Maria Al Matarneh, Isabela Andreea Sandu, Roxana Maria Amarandi, Lacramioara Popovici, Catalina Ionica Ciobanu, Dragos Peptanariu, Mariana Pinteala, Ionel I Mangalagiu and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Synthesis,RSC medicinal chemistry · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Microwave-Assisted Synthesis of Fluorescent Pyrido[2,3-Molecules (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Monica-Cornelia SardaruDepartment of Chemistry, Faculty of Chemistry, "Al. I. Cuza" University of Iasi, Iași, Romania.
Anda Mihaela CraciunDepartment of Chemistry, Faculty of Chemistry, "Al. I. Cuza" University of Iasi, Iași, Romania.
Cristina-Maria Al MatarnehDepartment of Chemistry, Faculty of Chemistry, "Al. I. Cuza" University of Iasi, Iași, Romania.
Isabela Andreea Sandu"Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy, Iași, Romania.
Roxana Maria AmarandiDepartment of Chemistry, Faculty of Chemistry, "Al. I. Cuza" University of Iasi, Iași, Romania.ORCID https://orcid.org/0000-0002-9937-6539
Lacramioara PopoviciDepartment of Chemistry, Faculty of Chemistry, "Al. I. Cuza" University of Iasi, Iași, Romania.
Catalina Ionica CiobanuResearch Department, Faculty of Chemistry, "Al. I. Cuza" University of Iasi, Iași, Romania.
Dragos Peptanariu"Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy, Iași, Romania.
Mariana Pinteala"Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy, Iași, Romania.
Ionel I MangalagiuDepartment of Chemistry, Faculty of Chemistry, "Al. I. Cuza" University of Iasi, Iași, Romania.ORCID https://orcid.org/0000-0002-4632-5076
Ramona DanacDepartment of Chemistry, Faculty of Chemistry, "Al. I. Cuza" University of Iasi, Iași, Romania.ORCID https://orcid.org/0000-0003-4370-5353
Alexandru Ioan Cuza University · RORomanian Academy · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A potential microtubule destabilising series of new indolizine derivatives was synthesised and tested for their anticancer activity against a panel of 60 human cancer cell lines. Compounds

Indexed as

Antineoplastic AgentsCell Line, TumorCell ProliferationColchicineDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansIndolizinesMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipTubulinTubulin ModulatorsAntineoplastic AgentsColchicineIndolizinesTubulinTubulin ModulatorsanticancerIndolizinePhenstatinpyridyltubulin polymerisation inhibitors

Identifiers

PMID32752898
PMCPMC7470029
OpenAlexW3047199761

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.