Evidence map›Paper›PMID 32752296›Full record

ArticleInternational journal of molecular sciences2020

Anti-Epileptic Effects of FABP3 Ligand MF1 through the Benzodiazepine Recognition Site of the GABA

Yasushi Yabuki, Jiaqi Liu, Ichiro Kawahata, Hisanao Izumi, Yasuharu Shinoda, Kohei Koga, Shinya Ueno, Norifumi Shioda, Kohji Fukunaga

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Yasushi YabukiDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Jiaqi LiuDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Ichiro KawahataDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.ORCID 0000-0002-5916-7847
Hisanao IzumiDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Yasuharu ShinodaDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.ORCID 0000-0001-9910-048X
Kohei KogaDepartment of Neurophysiology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan.
Shinya UenoDepartment of Neurophysiology, Graduate School of Medicine, Hirosaki University, Hirosaki 036-8216, Japan.
Norifumi ShiodaDepartment of Genomic Neurology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan.
Kohji FukunagaDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.ORCID 0000-0001-8526-2824
Tohoku University · JPHirosaki University · JPHyogo Medical University · JPKumamoto University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, we developed the fatty acid-binding protein 3 (FABP3) ligand MF1 (4-(2-(1-(2-chlorophenyl)-5-phenyl-1H-pyrazol-3-yl)phenoxy) butanoic acid) as a therapeutic candidate for α-synucleinopathies. MF1 shows affinity towards γ-aminobutyric acid type-A (GABA

Indexed as

AnimalsAnticonvulsantsBenzodiazepinesBinding SitesCell Line, TumorDiazepamFatty Acid Binding Protein 3FlumazenilLigandsMaleMice, Inbred ICRPentylenetetrazoleReceptors, GABA-ASeizuresStatus EpilepticusAnticonvulsantsBenzodiazepinesDiazepamFatty Acid Binding Protein 3FlumazenilLigandsPentylenetetrazoleReceptors, GABA-Aanti-epileptic effectbenzodiazepine recognition siteGABAA receptor

Identifiers

PMID32752296
PMCPMC7432285
OpenAlexW3046239382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.