Evidence map›Paper›PMID 32752261›Full record

ArticleInternational journal of molecular sciences2020

Noradrenergic Components of Locomotor Recovery Induced by Intraspinal Grafting of the Embryonic Brainstem in Adult Paraplegic Rats.

Anna Kwaśniewska, Krzysztof Miazga, Henryk Majczyński, Larry M Jordan, Małgorzata Zawadzka, Urszula Sławińska

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Anna KwaśniewskaNencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland.ORCID 0000-0002-2280-6465
Krzysztof MiazgaNencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland.ORCID 0000-0002-7536-0639
Henryk MajczyńskiNencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland.
Larry M JordanDepartment of Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Małgorzata ZawadzkaNencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland.
Urszula SławińskaNencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland.ORCID 0000-0003-2856-2729
Instytut Biologii Doświadczalnej im. Marcelego Nenckiego · PLUniversity of Manitoba · CA

Funding

CIHR PJT-152891Narodowe Centrum Badań i Rozwoju ERA-NET-Neuron/16/17
6 · The paper itself

Abstract

Intraspinal grafting of serotonergic (5-HT) neurons was shown to restore plantar stepping in paraplegic rats. Here we asked whether neurons of other phenotypes contribute to the recovery. The experiments were performed on adult rats after spinal cord total transection. Grafts were injected into the sub-lesional spinal cord. Two months later, locomotor performance was tested with electromyographic recordings from hindlimb muscles. The role of noradrenergic (NA) innervation was investigated during locomotor performance of spinal grafted and non-grafted rats using intraperitoneal application of α

Indexed as

Adrenergic alpha-2 Receptor AgonistsAdrenergic alpha-2 Receptor AntagonistsAnimalsBrain StemBrain Tissue TransplantationClonidineFemaleHindlimbLocomotionNerve RegenerationNeuronsParaplegiaRats, WistarRecovery of FunctionSpinal Cord InjuriesYohimbineAdrenergic alpha-2 Receptor AgonistsAdrenergic alpha-2 Receptor AntagonistsClonidineYohimbineembryonic brainstemserotoninspinal ratstransplantationα2 adrenergic receptors

Identifiers

PMID32752261
PMCPMC7432907
OpenAlexW3046367284

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.