ArticleInternational journal of environmental research and public health2020
Does the Caesarean Section Impact on 11β HSD2 and Fetal Cortisol?
Article in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Pediatrics Consequences of Caesarean Section-A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- Exposure to Endocrine Disruptors and Stress Hormones Across Pregnancy Trimesters: Links with Maternal Telomere Length.Journal of xenobiotics · 2026Article
- Comparison of advanced electronic intrapartum monitoring system (Keyar device and Daksh application) with standard cardiotocography for assessment of fetal heart rate and uterine contractions.Journal of family medicine and primary care · 2026Article
- Perinatal glucocorticoid sensitivity in the preterm newborn: molecular mechanisms, endogenous determinants, and clinical implications.Frontiers in endocrinology · 2025Review
- Biochemical analysis of catecholamine and cortisol for the evaluation of the fetal distress in third trimester stillbirths.International journal of legal medicine · 2024Article
- A Preliminary Study of Correlates of Premature Birth and Their Influence on Cortisol Levels in Young Children.Biological research for nursing · 2024Article
- Association of Plasma Cortisol Levels with Gestational Age and Anthropometric Values at Birth in Preterm Infants.International journal of environmental research and public health · 2022Article
- Prenatal maternal stress and offspring aggressive behavior: Intergenerational and transgenerational inheritance.Frontiers in behavioral neuroscience · 2022Review
- Sex Dimorphic Associations of Gestational Diabetes Mellitus With Cord Plasma Fatty Acid Binding Protein 4 and Estradiol.Frontiers in endocrinology · 2021Article
- Daylight Saving Time and Spontaneous Deliveries: A Case-Control Study in Italy.International journal of environmental research and public health · 2020Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeComparison of the activity of 11beta-hydroxysteroid dehydrogenase type 2 in the placenta and the umbilical cord blood cortisol level between caesarean sections with or without uterine contraction and vaginal delivery groups. Cortisol is the main stress hormone responsible for the normal adaptation of the neonate to extrauterine life. The disorders resulting from a dysfunction of the 11β-HSD 2-cortisol system can explain the higher risk of developing diseases in children born by caesarean section.
methods111 healthy, pregnant women in singular pregnancy at term of delivery were included into the study. The study comprised 11β-HSD 2 in placental tissue from 49 pregnant women delivering by elective caesarean section and 46 pregnant women delivering by vagina. In 16 cases of the elective caesarean section, regular uterine contractions were declared. Cortisol level was estimated in umbilical cord blood directly after delivery.
resultsWe found no statistically significant differences in the activity of 11β-HSD 2 in placentas delivered via caesarean sections (29.61 on average in elective caesarean sections and 26.65 on average in intrapartum caesarean sections) compared to vaginal deliveries (31.94 on average,
conclusionsThe model of placental 11β-HSD 2 activity and umbilical cord blood cortisol concentration seems to be significant in conditions of stress associated with natural uterine contractions in labour.
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Registered trials
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