Evidence map›Paper›PMID 32752134›Full record

ArticleInternational journal of molecular sciences2020

Ablation of Galectin-12 Inhibits Atherosclerosis through Enhancement of M2 Macrophage Polarization.

En-Shyh Lin, Yu-An Hsu, Ching-Yao Chang, Hui-Ju Lin, Chih Sheng Chen, Lei Wan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

En-Shyh LinDepartment of Beauty Science, National Taichung University of Science and Technology, Taichung 403, Taiwan.
Yu-An HsuSchool of Chinese Medicine, China Medical University, Taichung 404, Taiwan.
Ching-Yao ChangDepartment of Biotechnology, Asia University, Taichung 413, Taiwan.
Hui-Ju LinSchool of Chinese Medicine, China Medical University, Taichung 404, Taiwan.
Chih Sheng ChenDivision of Chinese Medicine, Asia University Hospital, Taichung 413, Taiwan.
Lei WanSchool of Chinese Medicine, China Medical University, Taichung 404, Taiwan.ORCID 0000-0002-9525-3232
Asia University · TWChina Medical University · TWNational Taichung University of Science and Technology · TW

Funding

China Medical University, Taiwan CMU108-ASIA-05China Medical University, Taiwan CMU108-MF-40Ministry of Science and Technology, Taiwan MOST107-2320-B-039-049-MY3
6 · The paper itself

Abstract

The formation of foam cells, which are macrophages that have engulfed oxidized low-density lipoprotein (OxLDL), constitutes the first stage in the development of atherosclerosis. Previously, we found that knocking down galectin-12, a negative regulator of lipolysis, leads to reduced secretion of monocyte chemoattractant protein-1 (MCP-1), a chemokine that plays an important role in atherosclerosis. This prompted us to study the role of galectin-12 in atherosclerosis. With that aim, we examined foam cell formation in Gal12

Indexed as

AnimalsAtherosclerosisATP Binding Cassette Transporter 1ATP Binding Cassette Transporter, Subfamily G, Member 1CD36 AntigensCell Cycle ProteinsCell PolarityDisease Models, AnimalFoam CellsGalectinsGene Expression RegulationHumansLipoproteins, LDLMacrophagesMiceMice, KnockoutATP Binding Cassette Transporter 1ATP Binding Cassette Transporter, Subfamily G, Member 1CD36 AntigensCell Cycle ProteinsGalectinsLgals12 protein, mouseLipoproteins, LDLoxidized low density lipoproteinReceptors, LDLScarb1 protein, mouseScavenger Receptors, Class Batherosclerosisfoam cellgalectin-12low-density lipoproteinmacrophage polarization

Identifiers

PMID32752134
PMCPMC7432701
OpenAlexW3046918388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.