Evidence map›Paper›PMID 32752102›Full record

ArticleInternational journal of molecular sciences2020

Persistent Human KIT Receptor Signaling Disposes Murine Placenta to Premature Differentiation Resulting in Severely Disrupted Placental Structure and Functionality.

Franziska Kaiser, Julia Hartweg, Selina Jansky, Natalie Pelusi, Caroline Kubaczka, Neha Sharma, Dominik Nitsche, Jan Langkabel, Hubert Schorle

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Franziska KaiserDepartment of Developmental Pathology, Institute of Pathology, University Hospital Bonn, 53127 Bonn, Germany.
Julia HartwegDepartment of Developmental Pathology, Institute of Pathology, University Hospital Bonn, 53127 Bonn, Germany.
Selina JanskyDepartment of Developmental Pathology, Institute of Pathology, University Hospital Bonn, 53127 Bonn, Germany.
Natalie PelusiDepartment of Developmental Pathology, Institute of Pathology, University Hospital Bonn, 53127 Bonn, Germany.
Caroline KubaczkaDepartment of Developmental Pathology, Institute of Pathology, University Hospital Bonn, 53127 Bonn, Germany.
Neha SharmaDepartment of Developmental Pathology, Institute of Pathology, University Hospital Bonn, 53127 Bonn, Germany.
Dominik NitscheDepartment of Developmental Pathology, Institute of Pathology, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0002-0589-503X
Jan LangkabelDepartment of Developmental Pathology, Institute of Pathology, University Hospital Bonn, 53127 Bonn, Germany.
Hubert SchorleDepartment of Developmental Pathology, Institute of Pathology, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0001-8272-0076
University Hospital Bonn · DEBoston Children's Hospital · USGerman Cancer Research Center · DENational University of Singapore · SGUniversity of Bonn · DE

Funding

Deutsche Forschungsgemeinschaft Scho 503 20/1
6 · The paper itself

Abstract

Activating mutations in the human KIT receptor is known to drive severe hematopoietic disorders and tumor formation spanning various entities. The most common mutation is the substitution of aspartic acid at position 816 to valine (D816V), rendering the receptor constitutively active independent of ligand binding. As the role of the KIT receptor in placental signaling cascades is poorly understood, we analyzed the impact of KIT

Indexed as

AnimalsFemaleGene Expression Regulation, DevelopmentalHomeobox A10 ProteinsHumansMAP Kinase Signaling SystemMiceNeoplasm InvasivenessPlacentaPlacental LactogenPlacentationPregnancyProlactinProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-kitTrophoblastsHomeobox A10 ProteinsHOXA10 protein, humanKIT protein, humanPlacental LactogenPrl2c2 protein, mouseProlactinProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-kitembryonic growth retardationinvasionKITD816VKIT receptorplacental developmentpremature differentiationspongiotrophoblasttrophoblast giant celltrophoblast stem cell

Identifiers

PMID32752102
PMCPMC7432075
OpenAlexW3046242401

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.