Evidence map›Paper›PMID 32752096›Full record

ReviewInternational journal of molecular sciences2020

Epigenetic Mechanisms in Gastric Cancer: Potential New Therapeutic Opportunities.

Matteo Canale, Andrea Casadei-Gardini, Paola Ulivi, Maria Arechederra, Carmen Berasain, Pier-Luigi Lollini, Maite G Fernández-Barrena, Matías A Avila

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  7. Review
  8. [High expression of CREM is associated with poor prognosis in gastric cancer patients].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
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  15. Article
  16. Article
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  18. Review
  19. LINC00562 drives gastric cancer development by regulating miR-4636-AP1S3 axis.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Matteo CanaleBiosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 47014 Meldola, Italy.ORCID 0000-0002-9768-7149
Andrea Casadei-GardiniDepartment of Oncology and Hematology, Division of Oncology, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Paola UliviBiosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 47014 Meldola, Italy.
Maria ArechederraProgram of Hepatology, Center for Applied Medical Research (CIMA), University of Navarra, 31008 Pamplona, Spain.ORCID 0000-0002-4830-1924
Carmen BerasainProgram of Hepatology, Center for Applied Medical Research (CIMA), University of Navarra, 31008 Pamplona, Spain.ORCID 0000-0001-7075-2476
Pier-Luigi LolliniLaboratory of Immunology and Biology of Metastasis, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, 40126 Bologna, Italy.ORCID 0000-0003-1702-4108
Maite G Fernández-BarrenaProgram of Hepatology, Center for Applied Medical Research (CIMA), University of Navarra, 31008 Pamplona, Spain.ORCID 0000-0003-0375-6236
Matías A AvilaProgram of Hepatology, Center for Applied Medical Research (CIMA), University of Navarra, 31008 Pamplona, Spain.ORCID 0000-0001-6570-3557

Funding

Asociación Española Contra el Cáncer (AECC) Post-doctoral fellowshipFundación La Caixa HEPACARE projectMinisterio de Ciencia e Innovación RYC2018-024475-1
6 · The paper itself

Abstract

Gastric cancer (GC) is one of the deadliest malignancies worldwide. Complex disease heterogeneity, late diagnosis, and suboptimal therapies result in the poor prognosis of patients. Besides genetic alterations and environmental factors, it has been demonstrated that alterations of the epigenetic machinery guide cancer onset and progression, representing a hallmark of gastric malignancies. Moreover, epigenetic mechanisms undergo an intricate crosstalk, and distinct epigenomic profiles can be shaped under different microenvironmental contexts. In this scenario, targeting epigenetic mechanisms could be an interesting therapeutic strategy to overcome gastric cancer heterogeneity, and the efforts conducted to date are delivering promising results. In this review, we summarize the key epigenetic events involved in gastric cancer development. We conclude with a discussion of new promising epigenetic strategies for gastric cancer treatment.

Indexed as

DNA MethylationEpigenesis, GeneticGene Expression Regulation, NeoplasticHumansStomachStomach Neoplasmsepigenetic mechanismsepigenetic therapiesgastric cancer

Identifiers

PMID32752096
PMCPMC7432799

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.