ArticleMolecules (Basel, Switzerland)2020
Preparative Separation of Flavonoids from Goji Berries by Mixed-Mode Macroporous Adsorption Resins and Effect on Aβ-Expressing and Anti-Aging Genes.
Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Bioactive spectrum of goji berries (Food chemistry: X · 2026Review
- Lycium L. flavonoids: extraction, purification, signal transduction pathways, and interactions with intestinal microbiota.NPJ science of food · 2026Review
- A Comprehensive Review of Phenolic Compounds in Horticultural Plants.International journal of molecular sciences · 2025Review
- Review
- Edible Berries-An Update on Nutritional Composition and Health Benefits-Part II.Current nutrition reports · 2025Review
- Continuous chromatography system with 6-zone and 18-column dynamic tandem connection technique for the enrichment of total flavonoids from Epimedium koreanum Nakai.Analytical and bioanalytical chemistry · 2025Article
- Preparation and Tumor Inhibitory Activity of Tricin from Carex Meyeriana Kunth.Molecules (Basel, Switzerland) · 2024Article
- A comprehensive review of goji berry processing and utilization.Food science & nutrition · 2023Review
- Transcriptional deciphering of the metabolic pathways associated with the bioactive ingredients of wolfberry species with different quality characteristics.BMC genomics · 2023Article
- Comparative Analysis of Polyphenols inMolecules (Basel, Switzerland) · 2023Article
- Pigment ofMolecules (Basel, Switzerland) · 2022Article
- Characterization and Evaluation of Antioxidant and Anti-Inflammatory Activities of Flavonoids from the Fruits ofFoods (Basel, Switzerland) · 2022Article
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Authors and funding
7 authors at 2 institutions in 1 country.
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Abstract
Flavonoids are the main constituents of Goji berries and have good biological and pharmacological activities. The mixed-mode macroporous adsorption resins (MARs) for purification of flavonoids from Goji berries through computer-assisted calculation of the molecular size of flavonoids and the precise matching of MAR physical and chemical properties was firstly developed in the present study. Ten varieties of MARs with suitable molecular dimensions and polarities were used for investigating the adsorption/desorption behaviors of the flavonoids. Both AUKJ-1 and BWKX-1 showed higher separation efficiency than other MARs and then were mixed in different ratios to constitute a mixed-mode macroporous adsorption resin to obtain the optimal adsorption phase. Under optimal conditions, total flavonoid content of purified flavonoid (p-FLA) extract increased from 0.97% to 36.88% after one purification. The p-FLA extract from Goji berries significantly improved the expression of six genes with anti-aging effects and played an important role in aging-related Alzheimer's disease by down-regulating Aβ expression.
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