ArticleMolecules (Basel, Switzerland)2020
Towards the Inhibition of Protein-Protein Interactions (PPIs) in STAT3: Insights into a New Class of Benzothiadiazole Derivatives.
Matteo Mori, Ettore Gilardoni, Luca Regazzoni, Alessandro Pedretti, Diego Colombo, Gary Parkinson, Akira Asai, Fiorella Meneghetti, Stefania Villa, Arianna Gelain
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Matteo MoriDepartment of Pharmaceutical Sciences, University of Milan, via L. Mangiagalli 25, 20133 Milano, Italy.ORCID 0000-0002-7491-1494 Ettore GilardoniDepartment of Pharmaceutical Sciences, University of Milan, via L. Mangiagalli 25, 20133 Milano, Italy.ORCID 0000-0002-2010-2667 Luca RegazzoniDepartment of Pharmaceutical Sciences, University of Milan, via L. Mangiagalli 25, 20133 Milano, Italy.ORCID 0000-0001-7199-7141 Alessandro PedrettiDepartment of Pharmaceutical Sciences, University of Milan, via L. Mangiagalli 25, 20133 Milano, Italy.ORCID 0000-0001-5916-2029 Diego ColomboDepartment of Medical Biotechnology and Translational Medicine, University of Milan, via C. Saldini 50, 20133 Milano, Italy.ORCID 0000-0003-1436-2304 Gary ParkinsonDepartment of Pharmaceutical and Biological Chemistry-UCL School of Pharmacy, University College London, 29/39 Brunswick Square, London WC1N 1AX, UK.ORCID 0000-0002-1865-9685 Akira AsaiCenter for Drug Discovery-Graduate School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
Fiorella MeneghettiDepartment of Pharmaceutical Sciences, University of Milan, via L. Mangiagalli 25, 20133 Milano, Italy.ORCID 0000-0002-6511-7360 Stefania VillaDepartment of Pharmaceutical Sciences, University of Milan, via L. Mangiagalli 25, 20133 Milano, Italy.ORCID 0000-0002-0636-7589 Arianna GelainDepartment of Pharmaceutical Sciences, University of Milan, via L. Mangiagalli 25, 20133 Milano, Italy.ORCID 0000-0001-9104-732X Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Signal transducer and activator of transcription 3 (STAT3) is a validated anticancer target due to the relationship between its constitutive activation and malignant tumors. Through a virtual screening approach on the STAT3-SH2 domain, 5,6-dimethyl-1
Indexed as
Binding SitesDrug DesignHumansMolecular Docking SimulationMutagenesis, Site-DirectedProtein Interaction Domains and Motifssrc Homology DomainsSTAT3 Transcription FactorStructure-Activity RelationshipThiadiazolesbenzo-1,2,3-thiadiazoleSTAT3 protein, humanSTAT3 Transcription FactorThiadiazolesbenzosulfamidescysteine binderdiversity-oriented synthesisSTAT3-SH2 domainstructure-based virtual screening
Identifiers
PMID32752073
PMCPMC7435819
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390