ArticleNutrients2020
Association between Biomarkers of Cardiovascular Diseases and the Blood Concentration of Carotenoids among the General Population without Apparent Illness.
Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Pooled it
- Trial
- Effects of Heat-KilledNutrients · 2021Trial
- The associations of plasma carotenoids andThe British journal of nutrition · 2026Article
- Blood and skin carotenoid levels are inversely associated with the prevalence of periodontal diseases in populations with normal occlusion: a cross-sectional analysis from the Iwaki health promotion project.Nutrition journal · 2026Article
- Interaction effects of dietary carotenoid intake and gamma-glutamyl transferase level on the prevalence of stroke in older adults.Journal of health, population, and nutrition · 2025Observational
- Higher skin carotenoid levels are associated with lower risks of metabolic syndrome: a cross-sectional study in Vietnamese participants.Frontiers in nutrition · 2025Article
- Associations between dietary carotenoid and biological age acceleration: insights from NHANES 2009-2018.Biogerontology · 2024Article
- A comparison of principal component analysis, reduced-rank regression, and partial least-squares in the identification of dietary patterns associated with cardiometabolic risk factors in Iranian overweight and obese women.BMC medical research methodology · 2024Article
- Differences of skin carotenoids and adherence to the Mediterranean Diet pattern in adults from Southern Italy and Dominican Republic.Journal of translational medicine · 2024Article
- A Narrative Review: The Effect and Importance of Carotenoids on Aging and Aging-Related Diseases.International journal of molecular sciences · 2023Review
- Article
- Chemistry, Occurrence, Properties, Applications, and Encapsulation of Carotenoids-A Review.Plants (Basel, Switzerland) · 2023Review
- Neoxanthin is undetectable in human blood after ingestion of fresh young spinach leaf.PloS one · 2023Article
- Effect of food processing on antioxidants, their bioavailability and potential relevance to human health.Food chemistry: X · 2022Review
- The Role of Bioactive Compounds in Natural Products Extracted from Plants in Cancer Treatment and Their Mechanisms Related to Anticancer Effects.Oxidative medicine and cellular longevity · 2022Review
- Inverse association of serum carotenoid levels with prevalence of hypertension in the general adult population.Frontiers in nutrition · 2022Article
- Article
- β-Carotene: Preventive Role for Type 2 Diabetes Mellitus and Obesity: A Review.Molecules (Basel, Switzerland) · 2020Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Several studies have demonstrated that carotenoid-rich vegetables are useful against cardiovascular diseases (CVDs). However, it is still unclear when a healthy population should start eating these vegetables to prevent CVDs. In this study, we evaluated the role of carotenoids in CVD markers in healthy subjects using age-stratified analysis. We selected 1350 subjects with no history of apparent illness who were undergoing health examinations. We then evaluated the relationship between the serum concentrations of six major carotenoids as well as their total, and nine CVD markers (i.e., body mass index (BMI), pulse wave velocity (PWV), systolic blood pressure (SBP), diastolic blood pressure (DBP), Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), blood insulin, fasting blood glucose (FBG), triglycerides (TGs), and high-density lipoprotein (HDL) cholesterol) using multiple regression analysis. It was found that the total carotenoid level was significantly associated with seven markers other than BMI and FBG in males and with eight markers other than DBP in females. Many of these relationships were independent of lifestyle habits. Many significant relationships were found in young males (aged 20-39) and middle-aged females (aged 40-59). These findings can be used as lifestyle guidance for disease prevention although the causal relationships should be confirmed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.