ArticleMolecules (Basel, Switzerland)2020
Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1.
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Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- MontmorilloniteEco-friendly and Effective Catalyst in the Synthesis of Biologically Active Compounds with Bicyclo[3.3.1] Moiety.ACS omega · 2025Article
- Validating TDP1 as an Inhibition Target for Lipophilic Nucleoside Derivative in Human Cells.International journal of molecular sciences · 2025Article
- New 5-Hydroxycoumarin-Based Tyrosyl-DNA Phosphodiesterase I Inhibitors Sensitize Tumor Cell Line to Topotecan.International journal of molecular sciences · 2023Article
- Natural Products and Their Derivatives as Inhibitors of the DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1.International journal of molecular sciences · 2023Review
- Transcriptomic Analysis of CRISPR/Cas9-Mediated PARP1-Knockout Cells under the Influence of Topotecan and TDP1 Inhibitor.International journal of molecular sciences · 2023Article
- Functional screening reveals HORMAD1-driven gene dependencies associated with translesion synthesis and replication stress tolerance.Oncogene · 2022Article
- Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs.Oncology and therapy · 2021Article
- New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1.International journal of molecular sciences · 2021Article
- A Dual-Sensor-Based Screening System for In Vitro Selection of TDP1 Inhibitors.Sensors (Basel, Switzerland) · 2021Article
- New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition.Biomolecules · 2021Article
- Novel Tdp1 Inhibitors Based on Adamantane Connected with Monoterpene Moieties via Heterocyclic Fragments.Molecules (Basel, Switzerland) · 2021Article
- Discovery of Novel Sultone Fused Berberine Derivatives as Promising Tdp1 Inhibitors.Molecules (Basel, Switzerland) · 2021Article
- Advances in Anticancer Drug Discovery.Molecules (Basel, Switzerland) · 2021Article
- Azaadamantanes, a New Promising Scaffold for Medical Chemistry.Russian journal of bioorganic chemistry · 2021Article
- The First Berberine-Based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme.International journal of molecular sciences · 2020Article
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Authors and funding
18 authors at 7 institutions in 4 countries.
Irina V Il'inaN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9, Lavrentiev Ave., 630090 Novosibirsk, Russia.
Nadezhda S DyrkheevaInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8, Lavrentiev Ave., 630090 Novosibirsk, Russia.
Alexandra L ZakharenkoInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8, Lavrentiev Ave., 630090 Novosibirsk, Russia.
Alexander Yu SidorenkoInstitute of Chemistry of New Materials of National Academy of Sciences of Belarus, Skaryna Str, 36, 220141 Minsk, Belarus.
Nikolay S Li-ZhulanovN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9, Lavrentiev Ave., 630090 Novosibirsk, Russia.
Dina V KorchaginaN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9, Lavrentiev Ave., 630090 Novosibirsk, Russia.
Raina ChandSchool of Chemical Sciences, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland 1142, New Zealand.
Daniel M Ayine-ToraSchool of Chemical Sciences, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland 1142, New Zealand.
Arina A ChepanovaInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8, Lavrentiev Ave., 630090 Novosibirsk, Russia.
Olga D ZakharovaInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8, Lavrentiev Ave., 630090 Novosibirsk, Russia.
Ekaterina S IlinaInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8, Lavrentiev Ave., 630090 Novosibirsk, Russia.
Jóhannes ReynissonSchool of Pharmacy and Bioengineering, Keele University, Hornbeam Building, Staffordshire ST5 5BG, UK.ORCID 0000-0003-4174-9512
Anastasia A MalakhovaInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8, Lavrentiev Ave., 630090 Novosibirsk, Russia.ORCID 0000-0003-1916-1333
Sergey P MedvedevFederal Research Centre Institute of Cytology and Genetics of the Siberian Branch of Russian Academy of Sciences, 10, Lavrentiev Ave, 630090 Novosibirsk, Russia.ORCID 0000-0002-1520-5549
Suren M ZakianNstitute of Cytology and Genetics, The Siberian Division of the Russian Academy of Sciences, Novosibirsk State University, 2, Pirogova Str., 630090 Novosibirsk, Russia.
Konstantin P VolchoN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9, Lavrentiev Ave., 630090 Novosibirsk, Russia.ORCID 0000-0002-4083-9324
Nariman F SalakhutdinovN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9, Lavrentiev Ave., 630090 Novosibirsk, Russia.
Olga I LavrikInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8, Lavrentiev Ave., 630090 Novosibirsk, Russia.ORCID 0000-0001-5980-8889
Institute of Chemical Biology and Fundamental Medicine · RURussian Academy of Sciences · RUNovosibirsk Institute of Organic Chemistry · RUUniversity of Auckland · NZInstitute of Chemistry of New Materials of the National Academy of Sciences of Belarus · BYInstitute of Cytology and Genetics · RUKeele University · GB
Funding
Russian Foundation for Basic Research 19-415-540002Russian Science Foundation 19-13-00040
Abstract
Two novel structural types of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors with hexahydroisobenzofuran
Indexed as
Drug DesignBicyclic MonoterpenesCell ProliferationCell SurvivalCRISPR-Cas SystemsDrug SynergismGene Knockout TechniquesHCT116 CellsHEK293 CellsHeLa CellsHumansInhibitory Concentration 50Phosphodiesterase InhibitorsPhosphoric Diester HydrolasesSignal TransductionTopotecan3-careneBicyclic MonoterpenesPhosphodiesterase InhibitorsPhosphoric Diester HydrolasesTDP1 protein, humanTopotecancareneinhibitormonoterpenesynergyTDP1 gene knockout cellstopotecantyrosyl-DNA phosphodiesterase 1
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.