Evidence map›Paper›PMID 32751917›Full record

ArticleBiomolecules2020

Structural Features Defining NF-κB Inhibition by Lignan-Inspired Benzofurans and Benzothiophenes.

Toan Dao-Huy, Simone Latkolik, Julia Bräuer, Andreas Pfeil, Hermann Stuppner, Michael Schnürch, Verena M Dirsch, Marko D Mihovilovic

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Toan Dao-HuyInstitute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9/163, 1060 Vienna, Austria.
Simone LatkolikDepartment of Pharmacognosy, University of Vienna, Althanstraße 14, 1090 Vienna, Austria.
Julia BräuerDepartment of Pharmacognosy, University of Vienna, Althanstraße 14, 1090 Vienna, Austria.
Andreas PfeilDepartment of Pharmacognosy, University of Vienna, Althanstraße 14, 1090 Vienna, Austria.
Hermann StuppnerInstitute of Pharmacy/Pharmacognosy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
Michael SchnürchInstitute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9/163, 1060 Vienna, Austria.ORCID 0000-0003-2946-9294
Verena M DirschDepartment of Pharmacognosy, University of Vienna, Althanstraße 14, 1090 Vienna, Austria.ORCID 0000-0002-9261-5293
Marko D MihovilovicInstitute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9/163, 1060 Vienna, Austria.ORCID 0000-0002-5438-8368
University of Vienna · ATTU Wien · ATUniversität Innsbruck · AT

Funding

Austrian Science Fund S 10710
6 · The paper itself

Abstract

A series of 2-arylbenzofurans and 2-arylbenzothiophenes was synthesized carrying three different side chains in position five. The synthesized compounds were tested for NF-κB inhibition to establish a structure activity relationship. It was found that both, the side chain in position five and the substitution pattern of the aryl moiety in position two have a significant influence on the inhibitory activity.

Indexed as

Anti-Inflammatory AgentsBenzofuransHEK293 CellsHumansLignansNF-kappa BStructure-Activity RelationshipThiophenesAnti-Inflammatory AgentsBenzofuransbenzothiopheneLignansNF-kappa BThiophenesC-H activationcross-couplingdirect arylationlignansnatural productNF-κB inhibition

Identifiers

PMID32751917
PMCPMC7463992
OpenAlexW3046419271

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.