ArticlePharmaceutics2020
Effects of Starch Incorporation on the Physicochemical Properties and Release Kinetics of Alginate-Based 3D Hydrogel Patches for Topical Delivery.
Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Precise Extrusion of Sweet Potato (Foods (Basel, Switzerland) · 2026Article
- Novel coating materials for glassionomer cement: formulation characteristics, surface adhesion and impact on microhardness.BMC oral health · 2026Article
- Novel Applications of Starch and Starch Derivatives in the Food and Alcoholic Beverages Industry: A Review.Foods (Basel, Switzerland) · 2026Review
- Collagen-Chitosan Composites Enhanced with Hydroxytyrosol for Prospective Wound Healing Uses.Pharmaceutics · 2025Article
- 3D-printed biopolymer-based microneedle for enhanced photodynamic therapy in melanoma treatment.Frontiers in oncology · 2025Review
- Biopolymer Drug Delivery Systems for Oromucosal Application: Recent Trends in Pharmaceutical R&D.International journal of molecular sciences · 2024Review
- Formulation and Evaluation of Transdermal Patches Containing BGP-15.Pharmaceutics · 2023Article
- Application of the Quality by Design Concept (QbD) in the Development of Hydrogel-Based Drug Delivery Systems.Polymers · 2023Review
- Low-Temperature 3D Printing Technology of Poly (Vinyl Alcohol) Matrix Conductive Hydrogel Sensors with Diversified Path Structures and Good Electric Sensing Properties.Sensors (Basel, Switzerland) · 2023Article
- Engineering 3D-Printed Advanced Healthcare Materials for Periprosthetic Joint Infections.Antibiotics (Basel, Switzerland) · 2023Review
- Patches as Polymeric Systems for Improved Delivery of Topical Corticosteroids: Advances and Future Perspectives.International journal of molecular sciences · 2022Review
- Niosomal Nanocarriers for Enhanced Dermal Delivery of Epigallocatechin Gallate for Protection against Oxidative Stress of the Skin.Pharmaceutics · 2022Article
- Polysaccharide 3D Printing for Drug Delivery Applications.Pharmaceutics · 2022Review
- 3D-Printed Products for Topical Skin Applications: From Personalized Dressings to Drug Delivery.Pharmaceutics · 2021Review
- Pre-Formulation Studies: Physicochemical Characteristics and In Vitro Release Kinetics of Insulin from Selected Hydrogels.Pharmaceutics · 2021Article
- Complying with the Guideline for Quality and Equivalence for Topical Semisolid Products: The Case of Clotrimazole Cream.Pharmaceutics · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The development of printable hydrogel inks for extrusion-based 3D printing is opening new possibilities to the production of new and/or improved pharmaceutical forms, specifically for topical application. Alginate and starch are natural polysaccharides that have been extensively exploited due to their biocompatibility, biodegradability, viscosity properties, low toxicity, and relatively low cost. This research work aimed to study the physicochemical and release kinetic effects of starch incorporation in alginate-based 3D hydrogel patches for topical delivery using a quality by design approach. The incorporation of a pregelatinized starch is also proposed as a way to improve the properties of the drug delivery system while maintaining the desired quality characteristics. Critical material attributes and process parameters were identified, and the sensitivity and adequacy of each parameter were statistically analyzed. The impact of alginate, starch, and CaCl
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.