Evidence map›Paper›PMID 32751735›Full record

ArticleCells2020

Toll-Like Receptor 2 Expression as a New Hallmark of Advanced Endometriosis.

Małgorzata Sobstyl, Paulina Niedźwiedzka-Rystwej, Ewelina Grywalska, Izabela Korona-Głowniak, Anna Sobstyl, Wiesława Bednarek, Jacek Roliński

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. A systematic review of toll-like receptors in endometriosis.Archives of gynecology and obstetrics · 2021
    Pooled it
  3. Review
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  5. Article
  6. Endometriosis: An Immunologist's Perspective.International journal of molecular sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Małgorzata SobstylChair and Department of Gynecology and Gynecological Endocrinology, Medical University of Lublin, 20-037 Lublin, Poland.
Paulina Niedźwiedzka-RystwejInstitute of Biology, University of Szczecin, 71-412 Szczecin, Poland.ORCID 0000-0003-4065-3842
Ewelina GrywalskaDepartment of Clinical Immunology and Immunotherapy, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0002-0451-4741
Izabela Korona-GłowniakDepartment of Pharmaceutical Microbiology, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0003-1634-0387
Anna SobstylDepartment of Clinical Immunology and Immunotherapy, Medical University of Lublin, 20-093 Lublin, Poland.
Wiesława BednarekI Chair and Department of Gynecological Oncology and Gynecology, Medical University of Lublin, 20-081 Lublin, Poland.
Jacek RolińskiDepartment of Clinical Immunology and Immunotherapy, Medical University of Lublin, 20-093 Lublin, Poland.
Medical University of Lublin · PLUniversity of Szczecin · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent evidence suggests that immunological aspects play a pivotal role in this disorder. Toll-like receptor 2 (TLR2) is crucial in recognizing microbial infections and mediating innate immune response. The objective of our study was to rate with flow cytometry the levels of several subsets of dendritic cells, monocytes, and basic peripheral blood lymphocytes expressing TLR2, aiming at the determination of a possible correlation between the expression of TLR2 and the clinical outcomes of endometriosis in 40 patients and 40 age-matched healthy women. Our study showed the importance of TLR2 expression, mainly on myeloid dendritic cells (mDCs) and B cells in patients with endometriosis. Both mDCs BDCA1+CD19-TLR2+ and B lymphocytes CD19+TLR-2+ proved useful in the differentiation of affected individuals with stages 3-4 of the disease (area under the receiver operating characteristic curve /AUC/ = 0.96,

Indexed as

AdultBiomarkersCase-Control StudiesDendritic CellsEndometriosisFemaleFlow CytometryHumansImmunity, InnateLymphocytesMiddle AgedMonocytesProspective StudiesROC CurveToll-Like Receptor 2BiomarkersTLR2 protein, humanToll-Like Receptor 2dendritic cellsendometriosisinnate immunitylymphocytesmonocytesToll-like receptor 2

Identifiers

PMID32751735
PMCPMC7464841
OpenAlexW3046715106

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.