Evidence map›Paper›PMID 32751680›Full record

ArticleVaccines2020

The Role of Virulence Proteins in Protection Conferred by

René H M Raeven, Naomi van Vlies, Merijn L M Salverda, Larissa van der Maas, Joost P Uittenbogaard, Tim H E Bindels, Jolanda Rigters, Lisa M Verhagen, Sabine Kruijer, Elly van Riet and 2 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Pathogens and global health · 2023
    Review
  5. Biological Nanoparticles in Vaccine Development.Frontiers in bioengineering and biotechnology · 2022
    Review
  6. Article
  7. Review
  8. Naturally circulating pertactin-deficientEmerging microbes & infections · 2021
    Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

René H M RaevenIntravacc (Institute for Translational Vaccinology), Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, The Netherlands.ORCID 0000-0002-1063-271X
Naomi van VliesIntravacc (Institute for Translational Vaccinology), Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, The Netherlands.
Merijn L M SalverdaIntravacc (Institute for Translational Vaccinology), Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, The Netherlands.ORCID 0000-0003-1361-9964
Larissa van der MaasIntravacc (Institute for Translational Vaccinology), Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, The Netherlands.
Joost P UittenbogaardIntravacc (Institute for Translational Vaccinology), Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, The Netherlands.
Tim H E BindelsIntravacc (Institute for Translational Vaccinology), Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, The Netherlands.
Jolanda RigtersIntravacc (Institute for Translational Vaccinology), Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, The Netherlands.
Lisa M VerhagenIntravacc (Institute for Translational Vaccinology), Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, The Netherlands.
Sabine KruijerIntravacc (Institute for Translational Vaccinology), Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, The Netherlands.
Elly van RietIntravacc (Institute for Translational Vaccinology), Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, The Netherlands.
Bernard MetzIntravacc (Institute for Translational Vaccinology), Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, The Netherlands.
Arno A J van der ArkIntravacc (Institute for Translational Vaccinology), Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, The Netherlands.
Intravacc (Netherlands) · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The limited protective immunity induced by acellular pertussis vaccines demands development of novel vaccines that induce broader and longer-lived immunity. In this study, we investigated the protective capacity of outer membrane vesicle pertussis vaccines (omvPV) with different antigenic composition in mice to gain insight into which antigens contribute to protection. We showed that total depletion of virulence factors (

Indexed as

2-dimensional gel electrophoresisantibody profilingBordetella pertussisbvgintranasal mouse challenge modelOMVouter membrane vesiclespertussis vaccineTh17virulence factors

Identifiers

PMID32751680
PMCPMC7563335
OpenAlexW3046792173

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.