Evidence map›Paper›PMID 32751583›Full record

ArticlePharmaceutics2020

Biopharmaceutical Assessment of Dexamethasone Acetate-Based Hydrogels Combining Hydroxypropyl Cyclodextrins and Polysaccharides for Ocular Delivery.

Roseline Mazet, Xurxo García-Otero, Luc Choisnard, Denis Wouessidjewe, Vincent Verdoot, Frédéric Bossard, Victoria Díaz-Tomé, Véronique Blanc-Marquis, Francisco-Javier Otero-Espinar, Anxo Fernandez-Ferreiro and 1 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Roseline MazetUniversity Grenoble Alpes, CNRS, DPM, 38000 Grenoble, France.
Xurxo García-OteroDepartment of Pharmacology, Pharmacy, Pharmaceutical Technology and Industrial Pharmacy Institute, Faculty of Pharmacy, University of Santiago de Compostela (USC), 15782 Santiago de Compostela, Spain.ORCID 0000-0002-8351-3180
Luc ChoisnardUniversity Grenoble Alpes, CNRS, DPM, 38000 Grenoble, France.
Denis WouessidjeweUniversity Grenoble Alpes, CNRS, DPM, 38000 Grenoble, France.
Vincent VerdootUniversity Grenoble Alpes, CNRS, Grenoble INP, LRP, 38000 Grenoble, France.
Frédéric BossardUniversity Grenoble Alpes, CNRS, Grenoble INP, LRP, 38000 Grenoble, France.
Victoria Díaz-ToméDepartment of Pharmacology, Pharmacy, Pharmaceutical Technology and Industrial Pharmacy Institute, Faculty of Pharmacy, University of Santiago de Compostela (USC), 15782 Santiago de Compostela, Spain.ORCID 0000-0003-0107-1292
Véronique Blanc-MarquisUniversity Grenoble Alpes, CNRS, DPM, 38000 Grenoble, France.
Francisco-Javier Otero-EspinarDepartment of Pharmacology, Pharmacy, Pharmaceutical Technology and Industrial Pharmacy Institute, Faculty of Pharmacy, University of Santiago de Compostela (USC), 15782 Santiago de Compostela, Spain.ORCID 0000-0001-9030-2253
Anxo Fernandez-FerreiroClinical Pharmacology Group, Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain.ORCID 0000-0002-7348-7337
Annabelle GèzeUniversity Grenoble Alpes, CNRS, DPM, 38000 Grenoble, France.
Centre National de la Recherche Scientifique · FRUniversidade de Santiago de Compostela · ESInstitut polytechnique de Grenoble · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We previously developed two optimized formulations of dexamethasone acetate (DXMa) hydrogels by means of special cubic mixture designs for topical ocular administration. These gels were elaborated with hydroxypropyl-β-CD (HPβCD) and hydroxypropyl-γ-CD (HPγCD) and commercial hydrogels in order to enhance DXMa water solubility and finally DXMa's ocular bioavailability and transcorneal penetration. The main objective of this study was to characterize them and to evaluate

Indexed as

cyclodextrinscytotoxicity studiesdexamethasone acetateeye dropshydrogelsradiolabeled ocular biopermanencerheologytranscorneal permeation

Identifiers

PMID32751583
PMCPMC7464375
OpenAlexW3045576798

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.