Evidence map›Paper›PMID 32751564›Full record

ArticleBiomedicines2020

Incomplete Pattern of Steroidogenic Protein Expression in Functioning Adrenocortical Carcinomas.

Sofia S Pereira, Madalena M Costa, Celso E Gomez-Sanchez, Mariana P Monteiro, Duarte Pignatelli

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Epigenomic Alterations of the HumanInternational journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Sofia S PereiraInstituto de Investigação e Inovação em Saúde (I3S), Universidade do Porto, 4200-135 Porto, Portugal.ORCID 0000-0001-6947-4560
Madalena M CostaEndocrine, Cardiovascular & Metabolic Research group, Multidisciplinary Unit for Biomedical Research (UMIB), University of Porto, 4050-313 Porto, Portugal.
Celso E Gomez-SanchezEndocrinology Section, G.V. (Sonny) Montgomery VA Medical Center, Jackson, MS 39216, USA.ORCID 0000-0002-9882-2082
Mariana P MonteiroEndocrine, Cardiovascular & Metabolic Research group, Multidisciplinary Unit for Biomedical Research (UMIB), University of Porto, 4050-313 Porto, Portugal.ORCID 0000-0002-0662-1831
Duarte PignatelliInstituto de Investigação e Inovação em Saúde (I3S), Universidade do Porto, 4200-135 Porto, Portugal.
Universidade do Porto · PTUniversity of Mississippi Medical Center · US

Funding

Fundação para a Ciência e a Tecnologia PTDC/MEC-ONC/31384/2017Fundação para a Ciência e a Tecnologia UID/ Multi/00215/2019
6 · The paper itself

Abstract

Autonomous steroid secretion is a common feature of adrenocortical carcinomas (ACC), although not always clinically evident owing to inefficient steroidogenesis with increased release of steroid precursors. Our study aim was to analyze the expression profile of four key proteins involved in the steroidogenesis cascade, in different adrenocortical tumors. Expression of proteins involved in steroidogenesis, namely steroidogenic acute regulatory protein (StAR), 11β-hydroxylase (CYP11B1), aldosterone synthase (CYP11B2) and 17α-hydroxylase (CYP17A1), were analyzed by immunohistochemistry in ACC (

Indexed as

11β-hydroxylaseadrenocortical carcinomasadrenocortical tumorsdifferential diagnosissteroidogenic enzymes

Identifiers

PMID32751564
PMCPMC7460193
OpenAlexW3046279122

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.