Evidence map›Paper›PMID 32751516›Full record

ArticleMolecules (Basel, Switzerland)2020

Bioactive Chemical Composition of Cannabis Extracts and Cannabinoid Receptors.

Yi Yang, Rupali Vyawahare, Melissa Lewis-Bakker, Hance A Clarke, Albert H C Wong, Lakshmi P Kotra

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Chemical Composition of Commercial Cannabis.Journal of agricultural and food chemistry · 2024
    Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yi YangDepartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada.
Rupali VyawahareCentre for Molecular Design and Preformulations, and Krembil Research Institute, University Health Network, Toronto, ON M5G 1L7, Canada.
Melissa Lewis-BakkerCentre for Molecular Design and Preformulations, and Krembil Research Institute, University Health Network, Toronto, ON M5G 1L7, Canada.
Hance A ClarkeDepartment of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, Toronto, ON M5G 1L7, Canada.ORCID 0000-0003-4975-3823
Albert H C WongCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, and the Departments of Psychiatry and Pharmacology, Faculty of Medicine, University of Toronto, Toronto, ON M5T 1R8, Canada.
Lakshmi P KotraDepartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada.ORCID 0000-0002-7071-4637

Funding

Canada Foundation for Innovation CFI 32350
6 · The paper itself

Abstract

Cannabis is widely used as a therapeutic drug, especially by patients suffering from psychiatric and neurodegenerative diseases. However, the complex interplay between phytocannabinoids and their targets in the human receptome remains largely a mystery, and there have been few investigations into the relationship between the chemical composition of medical cannabis and the corresponding biological activity. In this study, we investigated 59 cannabis samples used by patients for medical reasons. The samples were subjected to extraction (microwave and supercritical carbon dioxide) and chemical analyses, and the resulting extracts were assayed in vitro using the CB

Indexed as

AnimalsCannabinoidsCannabisCHO CellsChromatography, High Pressure LiquidCricetulusHumansPlant ExtractsQuantitative Structure-Activity RelationshipReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2CannabinoidsPlant ExtractsReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2cannabidiolcannabinoid receptorschemoinformaticsmedical cannabispartial least squares analysisquantitative structure-activity relationshiptetrahydrocannabinol

Identifiers

PMID32751516
PMCPMC7436063

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.