Evidence map›Paper›PMID 32751489›Full record

ArticleToxins2020

Enhanced Antimicrobial Activity of N-Terminal Derivatives of a Novel Brevinin-1 Peptide from The Skin Secretion of

Xiaowei Zhou, Yue Liu, Yitian Gao, Yuanxing Wang, Qiang Xia, Ruimin Zhong, Chengbang Ma, Mei Zhou, Xinping Xi, Chris Shaw and 4 more

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Antibacterial Activity of the Essential Oil FromFrontiers in microbiology · 2022
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

Xiaowei ZhouDepartment of Nutrition, Henry Fok School of Food Science and Engineering, Shaoguan University; Shaoguan 512005, China.
Yue LiuNatural Drug Discovery Group, School of Pharmacy, Queen's University, Belfast BT9 7BL, Northern Ireland, UK.
Yitian GaoCollege of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China.ORCID 0000-0002-5200-0155
Yuanxing WangState Key Lab of Food Science and Technology, Nanchang University, Nanchang 330047, China.
Qiang XiaDepartment of Food Science and Engineering, Key Laboratory of Animal Protein Food Processing Technology of Zhejiang Province, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315832, China.
Ruimin ZhongDepartment of Nutrition, Henry Fok School of Food Science and Engineering, Shaoguan University; Shaoguan 512005, China.
Chengbang MaNatural Drug Discovery Group, School of Pharmacy, Queen's University, Belfast BT9 7BL, Northern Ireland, UK.
Mei ZhouNatural Drug Discovery Group, School of Pharmacy, Queen's University, Belfast BT9 7BL, Northern Ireland, UK.ORCID 0000-0003-2576-0252
Xinping XiNatural Drug Discovery Group, School of Pharmacy, Queen's University, Belfast BT9 7BL, Northern Ireland, UK.
Chris ShawNatural Drug Discovery Group, School of Pharmacy, Queen's University, Belfast BT9 7BL, Northern Ireland, UK.
Tianbao ChenNatural Drug Discovery Group, School of Pharmacy, Queen's University, Belfast BT9 7BL, Northern Ireland, UK.ORCID 0000-0001-8011-9260
Di WuChemical Biology Research Centre, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou 325035, China.ORCID 0000-0001-5492-6106
Hang Fai KwokInstitute of Translational Medicine, Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau SAR.ORCID 0000-0002-6349-4517
Lei WangNatural Drug Discovery Group, School of Pharmacy, Queen's University, Belfast BT9 7BL, Northern Ireland, UK.ORCID 0000-0002-8811-8489
Queen's University Belfast · GBNanchang University · CNNingbo University · CNShaoguan University · CNUniversity of Macau · MOWenzhou Medical University · CNWenzhou University · CN

Funding

Jiangxi Science and Technology Support Program 20161BBF60095National Natural Science Foundation of China 31560478National Natural Science Foundation of China 81803345National Natural Science Foundation of China 81803590Research Project of Shaoguan University SZ2019ZK01Science and Technology Development Fund, Macau SAR 019/2017/A1Shaoguan Science and Technology Planning Project 2018sn157Shaoguan Social Development Science and Technology Planning Project 2018Sn080Wenzhou Municipal Science and Technology Bureau Y20180178Youth Innovative Talents Project of Education Department of Guangdong Province 2019KQNCX140
6 · The paper itself

Abstract

Antimicrobial peptides (AMPs) are promising therapeutic alternatives compared to conventional antibiotics for the treatment of drug-resistant bacterial infections. However, the application of the overwhelming majority of AMPs is limited because of the high toxicity and high manufacturing costs. Amphibian skin secretion has been proven to be a promising source for the discovery and development of novel AMPs. Herein, we discovered a novel AMP from the skin secretion of

Indexed as

Amphibian ProteinsAnimalsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesBacteriaBacterial Physiological PhenomenaBiofilmsCell Membrane PermeabilityErythrocytesHorsesLarvaMothsRanidaeSkinSkin Diseases, BacterialStaphylococcal InfectionsAmphibian ProteinsAnti-Bacterial AgentsAntimicrobial Cationic Peptidesantimicrobial activityskin-derived peptidesstabilitywaxworm model

Identifiers

PMID32751489
PMCPMC7472354
OpenAlexW3046752909

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.