ArticleJournal of clinical medicine2020
Lifestyle-Related Exposure to Cadmium and Lead is Associated with Diabetic Kidney Disease.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Environmental Cadmium Exposure Exacerbates Alzheimer's-like Pathology in a Gut Microbiota-Involved Manner.Toxics · 2026Article
- Association Between Blood Lead Levels and Diabetic Kidney Disease: A Cross-sectional Analysis of NHANES Data (1999-2018).Current molecular medicine · 2026Article
- Mechanistic insights into cadmium-induced hepatotoxicity mediated by dysregulation of microRNA expression.Frontiers in cell and developmental biology · 2026Article
- Environmental Exposure to Cadmium and Lead Exacerbates Kidney Function in People with Diabetes.Journal of xenobiotics · 2025Article
- Albuminuria in People Chronically Exposed to Low-Dose Cadmium Is Linked to Rising Blood Pressure Levels.Toxics · 2025Article
- Association between blood heavy metals and diabetic kidney disease among type 2 diabetic patients: a cross-sectional study.Scientific reports · 2024Article
- Potential role of serum copeptin among smoker T2DM patients with emphasis to ACE I/D gene polymorphism predicting DN.Scientific reports · 2024Article
- Exposure to cadmium and lead is associated with diabetic kidney disease in diabetic patients.Environmental health : a global access science source · 2024Article
- Review
- Evidence Linking Cadmium Exposure and βToxics · 2023Article
- Chronic Kidney Disease Induced by Cadmium and Diabetes: A Quantitative Case-Control Study.International journal of molecular sciences · 2023Article
- Cadmium-Induced Tubular Dysfunction in Type 2 Diabetes: A Population-Based Cross-Sectional Study.Toxics · 2023Article
- Association between urinary cadmium concentrations and liver function in adolescents.Environmental science and pollution research international · 2022Article
- Cadmium-Induced Kidney Injury: Oxidative Damage as a Unifying Mechanism.Biomolecules · 2021Review
- A Changing Perspective for Treatment of Chronic Kidney Disease.Journal of clinical medicine · 2021Article
- Integrated metabolomics coupled with pattern recognition and pathway analysis to reveal molecular mechanism of cadmium-induced diabetic nephropathy.Toxicology research · 2021Article
- Puerarin Restores Autophagosome-Lysosome Fusion to Alleviate Cadmium-Induced Autophagy Blockade via Restoring the Expression of Rab7 in Hepatocytes.Frontiers in pharmacology · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundEnvironmental factors contributing to diabetic kidney disease are incompletely understood. We investigated whether blood cadmium and lead concentrations were associated with the prevalence of diabetic kidney disease, and to what extent lifestyle-related exposures (diet and smoking) contribute to blood cadmium and lead concentrations. MATERIAL AND
methodsIn a cross-sectional analysis in 231 patients with type 2 diabetes included in the DIAbetes and LifEstyle Cohort Twente (DIALECT-1), blood cadmium and lead concentrations were determined using inductively coupled plasma mass spectrometry. The associations between diet (derived from food frequency questionnaire), smoking and cadmium and lead were determined using multivariate linear regression. The associations between cadmium and lead and diabetic kidney disease (albumin excretion >30 mg/24 h and/or creatinine clearance <60 mL/min/1.73 m
resultsMedian blood concentrations were 2.94 nmol/L (interquartile range (IQR): 1.78-4.98 nmol/L) for cadmium and 0.07 µmol/L (IQR: 0.04-0.09 µmol/L) for lead, i.e., below acute toxicity values. Every doubling of lead concentration was associated with a 1.75 (95% confidence interval (CI): 1.11-2.74) times higher risk for albuminuria. In addition, both cadmium (odds ratio (OR) 1.50 95% CI: 1.02-2.21) and lead (OR 1.83 95% CI: 1.07-3.15) were associated with an increased risk for reduced creatinine clearance. Both passive smoking and active smoking were positively associated with cadmium concentration. Alcohol intake was positively associated with lead concentration. No positive associations were found between dietary intake and cadmium or lead.
conclusionsThe association between cadmium and lead and the prevalence of diabetic kidney disease suggests cadmium and lead might contribute to the development of diabetic kidney disease. Exposure to cadmium and lead could be a so far underappreciated nephrotoxic mechanism of smoking and alcohol consumption.
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