Evidence map›Paper›PMID 32751375›Full record

ReviewInternational journal of molecular sciences2020

Functional Imaging for Therapeutic Assessment and Minimal Residual Disease Detection in Multiple Myeloma.

Bastien Jamet, Elena Zamagni, Cristina Nanni, Clément Bailly, Thomas Carlier, Cyrille Touzeau, Anne-Victoire Michaud, Philippe Moreau, Caroline Bodet-Milin, Françoise Kraeber-Bodere

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. New Developments in Myeloma Treatment and Response Assessment.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  5. Review
  6. Steps towards a Multiple Myeloma Cure?Journal of personalized medicine · 2022
    Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bastien JametNuclear Medicine/Hematology Department, Nantes University Hospital, F-44000 Nantes, France.ORCID 0000-0002-2145-9182
Elena ZamagniSeràgnoli Institute of Hematology, Bologna University School of Medicine, 40126 Bologna, Italy.ORCID 0000-0003-1422-7305
Cristina NanniNuclear Medicine Department, Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Clément BaillyNuclear Medicine/Hematology Department, Nantes University Hospital, F-44000 Nantes, France.ORCID 0000-0001-8313-3287
Thomas CarlierNuclear Medicine/Hematology Department, Nantes University Hospital, F-44000 Nantes, France.ORCID 0000-0002-6932-7322
Cyrille TouzeauNuclear Medicine/Hematology Department, Nantes University Hospital, F-44000 Nantes, France.ORCID 0000-0003-0275-2575
Anne-Victoire MichaudNuclear Medicine/Hematology Department, Nantes University Hospital, F-44000 Nantes, France.
Philippe MoreauNuclear Medicine/Hematology Department, Nantes University Hospital, F-44000 Nantes, France.
Caroline Bodet-MilinNuclear Medicine/Hematology Department, Nantes University Hospital, F-44000 Nantes, France.
Françoise Kraeber-BodereNuclear Medicine/Hematology Department, Nantes University Hospital, F-44000 Nantes, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serum markers and bone marrow examination are commonly used for monitoring therapy response in multiple myeloma (MM), but this fails to identify minimal residual disease (MRD), which frequently persists after therapy even in complete response patients, and extra-medullary disease escape. Positron emission tomography with computed tomography using 18F-deoxyglucose (FDG-PET/CT) is the reference imaging technique for therapeutic assessment and MRD detection in MM. To date, all large prospective cohort studies of transplant-eligible newly diagnosed MM patients have shown a strong and independent pejorative prognostic impact of not obtaining complete metabolic response by FDG-PET/CT after therapy, especially before maintenance. The FDG-PET/CT and MRD (evaluated by flow cytometry or next-generation sequencing at 10

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsBone MarrowDiffusion Magnetic Resonance ImagingDrug MonitoringFluorodeoxyglucose F18HumansLigandsMolecular ProbesMultiple MyelomaNeoplasm, ResidualPositron Emission Tomography Computed TomographyPrognosisProspective StudiesRadiopharmaceuticalsReceptors, CXCR4Remission InductionCXCR4 protein, humanFluorodeoxyglucose F18LigandsMolecular ProbesRadiopharmaceuticalsReceptors, CXCR4FDG-PET/CTimagingMMMRDprognostic valuetherapeutic assessment

Identifiers

PMID32751375
PMCPMC7432032

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.