Evidence map›Paper›PMID 32751327›Full record

ReviewInternational journal of molecular sciences2020

Non-Melanoma Skin Cancers: Biological and Clinical Features.

Mauro Cives, Francesco Mannavola, Lucia Lospalluti, Maria Chiara Sergi, Gerardo Cazzato, Elisabetta Filoni, Federica Cavallo, Giuseppe Giudice, Luigia Stefania Stucci, Camillo Porta and 1 more

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  19. The Role of Killer Ig-like Receptors in Diseases from A to Z.International journal of molecular sciences · 2025
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36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mauro CivesSection of Medical Oncology, Department of Biomedical Sciences and Clinical Oncology (DIMO), University of Bari 'Aldo Moro', 70121 Bari, Italy.ORCID 0000-0002-3013-1816
Francesco MannavolaSection of Medical Oncology, Department of Biomedical Sciences and Clinical Oncology (DIMO), University of Bari 'Aldo Moro', 70121 Bari, Italy.ORCID 0000-0003-2623-4166
Lucia LospallutiSection of Dermatology, Azienda Ospedaliero-Universitaria Policlinico di Bari, 70121 Bari, Italy.
Maria Chiara SergiSection of Medical Oncology, Department of Biomedical Sciences and Clinical Oncology (DIMO), University of Bari 'Aldo Moro', 70121 Bari, Italy.
Gerardo CazzatoSection of Pathology, University of Bari 'Aldo Moro', 70121 Bari, Italy.
Elisabetta FiloniSection of Medical Oncology, Department of Biomedical Sciences and Clinical Oncology (DIMO), University of Bari 'Aldo Moro', 70121 Bari, Italy.
Federica CavalloSection of Medical Oncology, Department of Biomedical Sciences and Clinical Oncology (DIMO), University of Bari 'Aldo Moro', 70121 Bari, Italy.
Giuseppe GiudiceSection of Plastic and Reconstructive Surgery, Department of Emergency and Organ Transplantation (DETO), University of Bari 'Aldo Moro', 70121 Bari, Italy.
Luigia Stefania StucciSection of Medical Oncology, Department of Biomedical Sciences and Clinical Oncology (DIMO), University of Bari 'Aldo Moro', 70121 Bari, Italy.
Camillo PortaSection of Medical Oncology, Department of Biomedical Sciences and Clinical Oncology (DIMO), University of Bari 'Aldo Moro', 70121 Bari, Italy.
Marco TucciSection of Medical Oncology, Department of Biomedical Sciences and Clinical Oncology (DIMO), University of Bari 'Aldo Moro', 70121 Bari, Italy.ORCID 0000-0003-4008-4897

Funding

Regione Puglia Precision Medicine Project
6 · The paper itself

Abstract

Non-melanoma skin cancers (NMSCs) include basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and Merkel cell carcinoma (MCC). These neoplasms are highly diverse in their clinical presentation, as well as in their biological evolution. While the deregulation of the Hedgehog pathway is commonly observed in BCC, SCC and MCC are characterized by a strikingly elevated mutational and neoantigen burden. As result of our improved understanding of the biology of non-melanoma skin cancers, innovative treatment options including inhibitors of the Hedgehog pathway and immunotherapeutic agents have been recently investigated against these malignancies, leading to their approval by regulatory authorities. Herein, we review the most relevant biological and clinical features of NMSC, focusing on innovative treatment approaches.

Indexed as

Gene Expression Regulation, NeoplasticAntibodies, MonoclonalAntigens, NeoplasmAntineoplastic Agents, ImmunologicalBasal Cell CarcinomaCarcinogenesisCarcinoma, Merkel CellCarcinoma, Squamous CellClinical Trials as TopicHedgehog ProteinsHumansImmunotherapyProgrammed Cell Death 1 ReceptorSignal TransductionSkin NeoplasmsAntibodies, MonoclonalAntigens, NeoplasmAntineoplastic Agents, ImmunologicalHedgehog ProteinsPDCD1 protein, humanProgrammed Cell Death 1 Receptoranti-PD1 monoclonal antibodiesbasal cell carcinomaHedgehog pathwayimmunotherapyMerkel cell carcinomaskin cancersquamous cell carcinoma

Identifiers

PMID32751327
PMCPMC7432795

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.