Evidence map›Paper›PMID 32751214›Full record

ArticleCancers2020

Circulating Exosomes Inhibit B Cell Proliferation and Activity.

Jan C Schroeder, Lisa Puntigam, Linda Hofmann, Sandra S Jeske, Inga J Beccard, Johannes Doescher, Simon Laban, Thomas K Hoffmann, Cornelia Brunner, Marie-Nicole Theodoraki and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 34 citations in OpenAlex.

  1. Tadalafil Enhances Immune Signatures in Response to Neoadjuvant Nivolumab in Resectable Head and Neck Squamous Cell Carcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Trial
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Tumor-derived Exosomes and Antitumor Immunity.Journal of immunology (Baltimore, Md. : 1950) · 2024
    Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Jan C SchroederDepartment of Otorhinolaryngology and Head and Neck Surgery, Ulm University, 89075 Ulm, Germany.ORCID 0000-0001-7000-4427
Lisa PuntigamDepartment of Otorhinolaryngology and Head and Neck Surgery, Ulm University, 89075 Ulm, Germany.
Linda HofmannDepartment of Otorhinolaryngology and Head and Neck Surgery, Ulm University, 89075 Ulm, Germany.ORCID 0000-0002-0683-7659
Sandra S JeskeDepartment of Otorhinolaryngology and Head and Neck Surgery, Ulm University, 89075 Ulm, Germany.
Inga J BeccardDepartment of Otorhinolaryngology and Head and Neck Surgery, Ulm University, 89075 Ulm, Germany.
Johannes DoescherDepartment of Otorhinolaryngology and Head and Neck Surgery, Ulm University, 89075 Ulm, Germany.
Simon LabanDepartment of Otorhinolaryngology and Head and Neck Surgery, Ulm University, 89075 Ulm, Germany.
Thomas K HoffmannDepartment of Otorhinolaryngology and Head and Neck Surgery, Ulm University, 89075 Ulm, Germany.
Cornelia BrunnerDepartment of Otorhinolaryngology and Head and Neck Surgery, Ulm University, 89075 Ulm, Germany.ORCID 0000-0002-6456-5508
Marie-Nicole TheodorakiDepartment of Otorhinolaryngology and Head and Neck Surgery, Ulm University, 89075 Ulm, Germany.
Patrick J SchulerDepartment of Otorhinolaryngology and Head and Neck Surgery, Ulm University, 89075 Ulm, Germany.ORCID 0000-0002-1065-8709
Universität Ulm · DE

Funding

Deutsche Forschungsgemeinschaft SCHU 2536/3Deutsche Forschungsgemeinschaft TH 2172/2-1
6 · The paper itself

Abstract

(1) Background: Head and neck squamous cell carcinoma (HNSCC) is characterized by a distinctive suppression of the anti-tumor immunity, both locally in the tumor microenvironment (TME) and the periphery. Tumor-derived exosomes mediate this immune suppression by directly suppressing T effector function and by inducing differentiation of regulatory T cells. However, little is known about the effects of exosomes on B cells. (2) Methods: Peripheral B cells from healthy donors and HNSCC patients were isolated and checkpoint receptor expression was analyzed by flow cytometry. Circulating exosomes were isolated from the plasma of HNSCC patients (

Indexed as

B cellsBruton’s tyrosine kinaseexosomesHead and Neck Cancer

Identifiers

PMID32751214
PMCPMC7464446
OpenAlexW3045591345

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.